[
   {
      "abstract" : "GeraldTaulo, Cora Goldie, Tayfun Lloyd-Esenkaya, Ruth Hynes, Caroline Paradise, Michael J. Proulx and Alexandra A. De Sousa",
      "creators" : [
         {
            "id" : "C.Jicol@bath.ac.uk",
            "institution" : "Centre for the Analysis of Motion, Entertainment Research & Applications",
            "name" : {
               "family" : "Jicol",
               "given" : "Crescent"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : null,
            "name" : {
               "family" : "Taulo",
               "given" : "Gerald"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : null,
            "name" : {
               "family" : "Goldie",
               "given" : "Cora"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : null,
            "name" : {
               "family" : "Lloyd-Esenkaya",
               "given" : "Tayfun"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : null,
            "name" : {
               "family" : "Hynes",
               "given" : "Ruth"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : null,
            "name" : {
               "family" : "Paradise",
               "given" : "Caroline"
            },
            "orcid" : null
         },
         {
            "id" : "M.J.Proulx@bath.ac.uk",
            "institution" : "Centre for the Analysis of Motion, Entertainment Research & Applications",
            "name" : {
               "family" : "Proulx",
               "given" : "Michael"
            },
            "orcid" : "0000-0003-4066-3645"
         },
         {
            "id" : "",
            "institution" : null,
            "name" : {
               "family" : "de Souza",
               "given" : "Alexandra"
            },
            "orcid" : null
         }
      ],
      "date" : "2023-01-31",
      "date_type" : "published",
      "issn" : "2624-9898",
      "language" : "english",
      "official_url" : "https://researchportal.bath.ac.uk/en/publications/the-effects-of-social-density-spatial-density-noise-and-office-vi",
      "publisher" : "Frontiers Media S.A.",
      "title" : "The Effects of Social Density, Spatial Density, Noise, and Office Views on Perceived Personal Space in the Virtual Workplace",
      "type" : "article"
   },
   {
      "abstract" : "                             Both E- and Z-N′-alkenyl urea derivatives of imidazolidinones may be formed selectively from enantiopure α-amino acids. Generation of their enolate derivatives in the presence of K                             +                              and [18]crown-6 induces intramolecular migration of the alkenyl group from N′ to Cα with retention of double bond geometry. DFT calculations indicate a partially concerted substitution mechanism. Hydrolysis of the enantiopure products under acid conditions reveals quaternary α-alkenyl amino acids with stereodivergent control of both absolute configuration and double bond geometry.",
      "creators" : [
         {
            "id" : "",
            "institution" : "School of Chemistry",
            "name" : {
               "family" : "Abas",
               "given" : "Hossay"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "School of Chemistry",
            "name" : {
               "family" : "Mas-Roselló",
               "given" : "Josep"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "School of Chemistry",
            "name" : {
               "family" : "Amer",
               "given" : "Mostafa Mahmoud"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "School of Chemistry",
            "name" : {
               "family" : "Durand",
               "given" : "Derek J."
            },
            "orcid" : null
         },
         {
            "id" : "R.R.Groleau@bath.ac.uk",
            "institution" : "Department of Chemistry",
            "name" : {
               "family" : "Groleau",
               "given" : "Robin R."
            },
            "orcid" : "0000-0003-0213-5198"
         },
         {
            "id" : "",
            "institution" : "School of Chemistry",
            "name" : {
               "family" : "Fey",
               "given" : "Natalie"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "School of Chemistry",
            "name" : {
               "family" : "Clayden",
               "given" : "Jonathan"
            },
            "orcid" : null
         }
      ],
      "date" : "2019-02-18",
      "date_type" : "published",
      "id_number" : "10.1002/anie.201813984",
      "issn" : "1433-7851",
      "language" : "english",
      "official_url" : "https://researchportal.bath.ac.uk/en/publications/asymmetric-and-geometry-selective-%CE%B1-alkenylation-of-%CE%B1-amino-acids",
      "publisher" : "WILEY-V C H VERLAG GMBH",
      "title" : "Asymmetric and Geometry-Selective α-Alkenylation of α-Amino Acids",
      "type" : "article"
   },
   {
      "abstract" : "The high renewables penetration results in increased imbalance volumes and balancing actions due to system stability requirements. The balancing market (BM) primarily turns down renewable generation and turns up traditional carbon-intensive generation in response to real-time energy imbalance. Existing dual-stage market mechanisms conflict with the carbon reduction trajectory by implementing balancing actions regardless of their carbon footprint. This paper proposes a novel carbon-oriented BM model to coordinate the environmental targets in the dayahead (DA) and real-time BMs. The emissions of dispatchable generators and flexible loads are distinguished by their operation modes and flexibility types, respectively. Carbon signals are incorporated into their bid/offer prices through the proposed carbon emission flow (CEF) model. By integrating these carbon incentives, the dual-stage market model is formulated to minimize economic and environmental costs. Simulation results demonstrate that, overall, although the proposed BM mechanism results in an increased cost of balancing services (159.10 m£), there is a concurrent larger drop in carbon costs (294.14 m£), resulting in a reduction in total cost. It enables system operators to incentivize decarbonized energy resources in DA scheduling and real-time balancing actions.",
      "creators" : [
         {
            "id" : "sc2791@bath.ac.uk",
            "institution" : "Department of Electronic & Electrical Engineering",
            "name" : {
               "family" : "Cheng",
               "given" : "Shuang"
            },
            "orcid" : "0000-0002-1002-4407"
         },
         {
            "id" : "",
            "institution" : "Newcastle University",
            "name" : {
               "family" : "Scholes",
               "given" : "Susan C."
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "University of Manchester",
            "name" : {
               "family" : "Kong",
               "given" : "Wangwei"
            },
            "orcid" : null
         },
         {
            "id" : "C.Gu@bath.ac.uk",
            "institution" : "Department of Electronic & Electrical Engineering",
            "name" : {
               "family" : "Gu",
               "given" : "Chenghong"
            },
            "orcid" : "0000-0002-3306-767X"
         },
         {
            "id" : "F.Li@bath.ac.uk",
            "institution" : "Department of Electronic & Electrical Engineering",
            "name" : {
               "family" : "Li",
               "given" : "Furong"
            },
            "orcid" : null
         }
      ],
      "date" : "2022-12-26",
      "date_type" : "published",
      "id_number" : "10.1109/TPWRS.2022.3229488",
      "issn" : "0885-8950",
      "language" : "english",
      "official_url" : "https://researchportal.bath.ac.uk/en/publications/carbon-oriented-electricity-balancing-market-for-dispatchable-gen",
      "publisher" : "IEEE",
      "title" : "Carbon-Oriented Electricity Balancing Market for Dispatchable Generators and Flexible Loads",
      "type" : "article"
   },
   {
      "abstract" : "Water resources are vital to the energy conversion process but few efforts have been devoted to the joint optimization problem which is fundamentally critical to the water-energy nexus for small-scale or remote energy systems (e.g., energy hubs). Traditional water and energy trading mechanisms depend on centralized authorities and cannot preserve security and privacy effectively. Also, their transaction process cannot be verified and is subject to easy tampering and frequent exposures to cyberattacks, forgery, and network failures. Toward that end, water-energy hubs (WEHs) offers a promising way to analyse water-energy nexus for greater resource utilization efficiency. We propose a two-stage blockchain-based transactive management method for multiple, interconnected WEHs. Our method considers peer-topeer (P2P) trading and demand response, and leverages blockchain to create a secure trading environment. It features auditing and resource transaction record management via system aggregators enabled by a consortium blockchain, and entails spatial-temporal distributionally robust optimization (DRO) for renewable generation and load uncertainties. A spatial-temporal ambiguity set is incorporated in DRO to characterize the spatial-temporal dependencies of the uncertainties in distributed renewable generation and load demand. We conduct a simulation-based evaluation that includes robust optimization and the moment-based DRO as benchmarks. The results reveal that our method is consistently more effective than both benchmarks. Key findings include i) our method reduces conservativeness with lower WEH trading and operation costs, and achieves important performance improvements by up to 6.1%; and ii) our method is efficient and requires 18.7% less computational time than the moment-based DRO. Overall, this study contributes to the extant literature by proposing a novel two-stage blockchain-based WEH transaction method, developing a realistic spatialtemporal ambiguity set to effectively hedge against the uncertainties for distributed renewable generation and load demand, and producing empirical evidence suggesting its greater effectiveness and values than several prevalent methods.",
      "creators" : [
         {
            "id" : "",
            "institution" : "Department of Electronic & Electrical Engineering",
            "name" : {
               "family" : "Zhao",
               "given" : "Pengfei"
            },
            "orcid" : null
         },
         {
            "id" : "sl2908@bath.ac.uk",
            "institution" : "Department of Electronic & Electrical Engineering",
            "name" : {
               "family" : "Li",
               "given" : "Shuangqi"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "University of Utah",
            "name" : {
               "family" : "Hu",
               "given" : "Paul Jen Hwa"
            },
            "orcid" : null
         },
         {
            "id" : "C.Gu@bath.ac.uk",
            "institution" : "Department of Electronic & Electrical Engineering",
            "name" : {
               "family" : "Gu",
               "given" : "Chenghong"
            },
            "orcid" : "0000-0002-3306-767X"
         },
         {
            "id" : "",
            "institution" : "Southeast University",
            "name" : {
               "family" : "Lu",
               "given" : "Shuai"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "Southeast University",
            "name" : {
               "family" : "Ding",
               "given" : "Shixing"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "Chinese Academy of Sciences",
            "name" : {
               "family" : "Cao",
               "given" : "Zhidong"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "Shanghai Jiao Tong University",
            "name" : {
               "family" : "Xie",
               "given" : "Da"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "Sichuan University",
            "name" : {
               "family" : "Xiang",
               "given" : "Yue"
            },
            "orcid" : null
         }
      ],
      "date" : "2022-12-20",
      "date_type" : "published",
      "id_number" : "10.1109/TSG.2022.3230693",
      "issn" : "1949-3053",
      "language" : "english",
      "official_url" : "https://researchportal.bath.ac.uk/en/publications/blockchain-based-water-energy-transactive-management-with-spatial",
      "publisher" : "IEEE",
      "title" : "Blockchain-Based Water-Energy Transactive Management with Spatial-Temporal Uncertainties",
      "type" : "article"
   },
   {
      "abstract" : "One of the most fundamental interactions -pointing- is well understood on flat surfaces. However, pointing performance on tangible surfaces with physical targets is still limited for Tangible User Interfaces (TUIs). We investigate the effect of a target's physical width, height, and distance on user pointing performance. We conducted a study using a reciprocal tapping task (n=19) with physical rods arranged in a circle. We compared our data with five conventional interaction models designed for 2D/3D tasks rather than tangible targets. We show that variance in the movement times was only satisfactorily explained by a model established for volumetric displays (r2=0.954). Analysis shows that movement direction and height should be included as parameters to this model to generalize for 3D tangible targets. Qualitative feedback from participants suggests that pointing at physical targets involves additional human factors (e.g., perception of sharpness or robustness) that need to be investigated further to understand how performance with tangible objects is affected.",
      "creators" : [
         {
            "id" : "",
            "institution" : "University of Oxford",
            "name" : {
               "family" : "Everitt",
               "given" : "Aluna"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "University of Bristol",
            "name" : {
               "family" : "Roudaut",
               "given" : "Anne"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "University of Copenhagen",
            "name" : {
               "family" : "Hornbæk",
               "given" : "Kasper"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "University of Bristol",
            "name" : {
               "family" : "Fraser",
               "given" : "Mike"
            },
            "orcid" : null
         },
         {
            "id" : "jma73@bath.ac.uk",
            "institution" : "Department of Computer Science",
            "name" : {
               "family" : "Alexander",
               "given" : "Jason"
            },
            "orcid" : "0000-0001-6093-6116"
         }
      ],
      "date" : "2022-12-31",
      "date_type" : "published",
      "id_number" : "10.1145/3567736",
      "issn" : "2573-0142",
      "language" : "english",
      "official_url" : "https://researchportal.bath.ac.uk/en/publications/investigating-pointing-performance-for-tangible-surfaces-with-phy",
      "publisher" : "Association for Computing Machinery",
      "title" : "Investigating Pointing Performance for Tangible Surfaces with Physical 3D Targets",
      "type" : "article"
   },
   {
      "abstract" : "Accurate knowledge of particle density is essential for many aspects of aerosol science. Yet, density is often characterized poorly and incompletely for internally mixed particles, particularly for dry particles, with previous studies focused primarily on deliquescent (aqueous) droplets. Instead, densities for dry internally mixed particles are often inferred from mass composition measurements in combination with predictive models assuming ideal mixing, with the accuracy of such models not estimated. We determined particle densities from mobility diameter measurements (using a Scanning Mobility Particle Sizer, SMPS) for dried particles classified by their aerodynamic size (using an Aerosol Aerodynamic Classifier, AAC) for a range of two-component organic-inorganic particles containing known proportions of organic and inorganic species. We examined all permutations of mixing between four different organic (water soluble nigrosin dye, citric acid, polyethylene glycol-400, and ascorbic acid) and three different inorganic (sodium chloride, ammonium sulfate, and sodium nitrate) species. The accuracy and precision in our measured particle densities were ∼5% and ∼1%, respectively, for nonvolatile particles. Substantial deviations in particle density from ideal mixing (up to 20%) were observed. We tested descriptions of the non-ideal mixing for our systems by representing the volume change of mixing using Redlich-Kister (RK) polynomials in terms of mass fraction or in terms of mole fraction, with both approaches performing similarly.",
      "creators" : [
         {
            "id" : "",
            "institution" : "University of Bristol",
            "name" : {
               "family" : "Vokes",
               "given" : "Elinor T."
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "Brookhaven National Laboratory",
            "name" : {
               "family" : "Lewis",
               "given" : "Ernie R."
            },
            "orcid" : null
         },
         {
            "id" : "A.L.Johnson@bath.ac.uk",
            "institution" : "Department of Chemistry",
            "name" : {
               "family" : "Johnson",
               "given" : "Andrew L."
            },
            "orcid" : "0000-0001-5241-0878"
         },
         {
            "id" : "",
            "institution" : "University of Bristol",
            "name" : {
               "family" : "Cotterell",
               "given" : "Michael I."
            },
            "orcid" : null
         }
      ],
      "date" : "2022-04-28",
      "date_type" : "published",
      "id_number" : "10.1080/02786826.2022.2062293",
      "issn" : "0278-6826",
      "language" : "english",
      "official_url" : "https://researchportal.bath.ac.uk/en/publications/densities-of-internally-mixed-organic-inorganic-particles-from-mo",
      "publisher" : "Taylor and Francis",
      "title" : "Densities of internally mixed organic-inorganic particles from mobility diameter measurements of aerodynamically classified aerosols",
      "type" : "article"
   },
   {
      "creators" : [
         {
            "id" : "T.D.James@bath.ac.uk",
            "institution" : "Centre for Biosensors, Bioelectronics and Biodevices (C3Bio)",
            "name" : {
               "family" : "James",
               "given" : "Tony"
            },
            "orcid" : "0000-0002-4095-2191"
         }
      ],
      "date" : "2022-09-23",
      "date_type" : "published",
      "id_number" : "10.1039/D2CS00650B",
      "issn" : "0306-0012",
      "language" : "english",
      "official_url" : "https://researchportal.bath.ac.uk/en/publications/title-fluorescent-probes-for-the-detection-of-chemical-warfare-ag",
      "publisher" : "Royal Society of Chemistry",
      "title" : "Title Fluorescent probes for the detection of chemical warfare agents",
      "type" : "article"
   },
   {
      "abstract" : "Motivation: Many mainstream welfare theories developed by social scientists and applied by economists and policy-makers underestimate families' roles in providing welfare to citizens. This is surprising given that the family constitutes one of the main welfare pillars across typologies of the welfare state. Purpose: This article seeks to explore the role of the family as a welfare pillar with an ageing perspective. We aimed to test whether the family serves as a space for negotiations to improve wellbeing and achieve security in the absence of effective formal mechanisms. Methods and approach: Applying the framework of “informal security regimes,” this article draws on 37 life-history interviews collected from older persons living in extreme poverty in Bangladesh. Recurring themes are identified and analysed to explore the relationship between family and wellbeing/security. Findings: We find that family relationships are often central in the pursuit of security. This shows how welfare delivery in low and middle-income countries (LMICs), in this case Bangladesh, is deeply rooted in reciprocal family systems where all members actively fulfil moral and material expectations. Pursuing this collective goal can take different forms relative to each member's physical and mental capacity, position, gender, and age. Building on the empirical evidence, we propose the concept of “relational security” as a crucial marker and shaper of wellbeing. Policy implications: To be effective, welfare policies need to better consider how the conception and experiences of wellbeing and security, especially for the older persons living in extreme poverty, are deeply embedded within the complex functioning of the relationships that can shape welfare outcomes in different directions.",
      "creators" : [
         {
            "id" : "",
            "institution" : "Örebro University",
            "name" : {
               "family" : "Akram",
               "given" : "Owasim"
            },
            "orcid" : null
         },
         {
            "id" : "mm880@bath.ac.uk",
            "institution" : "Department of Social & Policy Sciences",
            "name" : {
               "family" : "Maîtrot",
               "given" : "Mathilde"
            },
            "orcid" : "0000-0001-9365-6380"
         }
      ],
      "date" : "2022-11-17",
      "date_type" : "published",
      "id_number" : "10.1111/dpr.12679",
      "issn" : "0950-6764",
      "language" : "english",
      "official_url" : "https://researchportal.bath.ac.uk/en/publications/familys-roles-as-a-welfare-pillar-the-case-of-older-persons-livin",
      "publisher" : "Wiley-Blackwell",
      "title" : "Family's roles as a welfare pillar: The case of older persons living in extreme poverty in Bangladesh",
      "type" : "article"
   },
   {
      "creators" : [
         {
            "id" : "ajgl21@bath.ac.uk",
            "institution" : "Institute for Policy Research (IPR)",
            "name" : {
               "family" : "Garcia-Lazaro",
               "given" : "Aida"
            },
            "orcid" : "0000-0002-1545-3278"
         }
      ],
      "date" : "2023-01-24",
      "date_type" : "published",
      "issn" : "0147-5967",
      "language" : "english",
      "official_url" : "https://researchportal.bath.ac.uk/en/publications/intangible-capital-the-labour-share-and-national-growth-regimes",
      "publisher" : "Elsevier Academic Press Inc",
      "title" : "Intangible capital, the labour share and national ‘growth regimes’",
      "type" : "article"
   },
   {
      "creators" : [
         {
            "id" : "ok433@bath.ac.uk",
            "institution" : "Department of Social & Policy Sciences",
            "name" : {
               "family" : "Khan",
               "given" : "Omar Phoenix"
            },
            "orcid" : null
         }
      ],
      "date" : "2020-05-18",
      "date_type" : "published",
      "issn" : "2202-7998",
      "language" : "english",
      "official_url" : "https://researchportal.bath.ac.uk/en/publications/roxana-pessoa-cavalcanti-2020-a-southern-criminology-of-violence-",
      "publisher" : "Queensland Uuniversity of Technology",
      "title" : "Roxana Pessoa Cavalcanti (2020) A Southern Criminology of Violence, Youth and Policing: Governing Insecurity in Urban Brazil. New York, NY: Routledge",
      "type" : "article"
   },
   {
      "abstract" : "This paper examines the role of product quality expectations. Past research on information cues, scarcity, self-congruity, product quality and satisfaction are synthesized to develop a conceptual model. This model examines how consumer expectations of product quality are formed. A number of antecedent factors and their relationship to consumers' product quality expectations are discussed. How consumer expectations of quality affects their product evaluation both during the pre-purchase stage and during the post-purchase stage are discussed. A number of theoretical propositions are presented. Finally, the implications of the conceptual model are discussed.",
      "creators" : [
         {
            "id" : "dg734@bath.ac.uk",
            "institution" : "Management",
            "name" : {
               "family" : "Grewal",
               "given" : "Dhruv"
            },
            "orcid" : "0000-0002-7046-6063"
         }
      ],
      "date" : "1995-03-31",
      "date_type" : "published",
      "id_number" : "10.1007/BF02230967",
      "issn" : "0889-3268",
      "language" : "english",
      "official_url" : "https://researchportal.bath.ac.uk/en/publications/product-quality-expectations-towards-an-understanding-of-their-an",
      "publisher" : "Kluwer Academic/Human Sciences Press Inc.",
      "title" : "Product quality expectations: Towards an understanding of their antecedents and consequences",
      "type" : "article"
   },
   {
      "abstract" : "In this article, the authors first propose a simple model summarizing the key drivers of customer loyalty. Then, on the basis of this model and drawing on key insights from the preceding articles in this issue, they outline a set of issues for further research related to the quality-value-loyalty chain. Next, the authors develop a conceptual framework that integrates the quality-value-loyalty chain with the \"pyramid model,\" which emphasizes the increasing importance of technology-customer, technology-employee, and technology-company linkages in serving customers. Using this integrated framework as a spring-board, they identify a number of avenues for additional inquiry pertaining to the three types of linkages.",
      "creators" : [
         {
            "id" : "",
            "institution" : "University of Miami",
            "name" : {
               "family" : "Parasuraman",
               "given" : "A."
            },
            "orcid" : null
         },
         {
            "id" : "dg734@bath.ac.uk",
            "institution" : "Management",
            "name" : {
               "family" : "Grewal",
               "given" : "Dhruv"
            },
            "orcid" : "0000-0002-7046-6063"
         }
      ],
      "date" : "2000",
      "date_type" : "published",
      "id_number" : "10.1177/0092070300281015",
      "issn" : "0092-0703",
      "language" : "english",
      "official_url" : "https://researchportal.bath.ac.uk/en/publications/the-impact-of-technology-on-the-quality-value-loyalty-chain-a-res",
      "publisher" : "Springer New York",
      "title" : "The impact of technology on the quality-value-loyalty chain: A research agenda",
      "type" : "article"
   },
   {
      "creators" : [
         {
            "id" : "C.Ashwin@bath.ac.uk",
            "institution" : "Department of Psychology",
            "name" : {
               "family" : "Ashwin",
               "given" : "Chris"
            },
            "orcid" : "0000-0003-4606-7318"
         }
      ],
      "date" : "2023-01-26",
      "date_type" : "published",
      "id_number" : "https://doi.org/10.1371/journal.pone.0275903",
      "issn" : "1932-6203",
      "language" : "english",
      "official_url" : "https://researchportal.bath.ac.uk/en/publications/the-validation-of-a-mandarin-version-of-the-empathy-components-qu",
      "publisher" : "Public Library of Science (PLOS)",
      "title" : "The validation of a Mandarin version of the Empathy Components Questionnaire (ECQ-Chinese) in Chinese samples.",
      "type" : "article"
   },
   {
      "creators" : [
         {
            "id" : "fgg26@bath.ac.uk",
            "institution" : "Department of Chemical Engineering",
            "name" : {
               "family" : "Guler Gencer",
               "given" : "Fatma"
            },
            "orcid" : "0000-0003-4385-1131"
         },
         {
            "id" : "",
            "institution" : "Ankara University",
            "name" : {
               "family" : "Ozcelik",
               "given" : "Filiz"
            },
            "orcid" : null
         }
      ],
      "date" : "2018-10-15",
      "date_type" : "published",
      "language" : "english",
      "official_url" : "https://researchportal.bath.ac.uk/en/publications/determination-of-xylanase-activity-of-indigenous-bacillus-species",
      "title" : "Determination of Xylanase Activity of Indigenous Bacillus Species Isolated from Food and Agricultural Wastes",
      "type" : "article"
   },
   {
      "creators" : [
         {
            "id" : "snm28@bath.ac.uk",
            "institution" : "Department of Chemistry",
            "name" : {
               "family" : "McCormick",
               "given" : "Strachan"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : null,
            "name" : {
               "family" : "Gobius Du Sart",
               "given" : "Gerrit"
            },
            "orcid" : null
         },
         {
            "id" : "M.Jones2@bath.ac.uk",
            "institution" : "Centre for Sustainable and Circular Technologies (CSCT)",
            "name" : {
               "family" : "Jones",
               "given" : "Matthew"
            },
            "orcid" : "0000-0001-5991-5617"
         },
         {
            "id" : "",
            "institution" : null,
            "name" : {
               "family" : "Russell",
               "given" : "Andrew"
            },
            "orcid" : null
         },
         {
            "id" : "M.G.Davidson@bath.ac.uk",
            "institution" : "Made Smarter Innovation: Centre for People-Led Digitalisation ",
            "name" : {
               "family" : "Davidson",
               "given" : "Matthew"
            },
            "orcid" : null
         },
         {
            "id" : "A.Buchard@bath.ac.uk",
            "institution" : "Department of Chemistry",
            "name" : {
               "family" : "Buchard",
               "given" : "Antoine"
            },
            "orcid" : "0000-0003-3417-5194"
         },
         {
            "id" : "C.Chuck@bath.ac.uk",
            "institution" : "Centre for Integrated Bioprocessing Research (CIBR)",
            "name" : {
               "family" : "Chuck",
               "given" : "Chris"
            },
            "orcid" : "0000-0003-0804-6751"
         }
      ],
      "date" : "2023-01-20",
      "date_type" : "published",
      "id_number" : "10.1021/acscatal.2c05690",
      "issn" : "2155-5435",
      "language" : "english",
      "official_url" : "https://researchportal.bath.ac.uk/en/publications/a-highly-active-and-selective-zirconium-based-catalyst-system-for",
      "publisher" : "American Chemical Society",
      "title" : "A Highly Active and Selective Zirconium-based Catalyst System for the Industrial Production of Poly(lactic acid)",
      "type" : "article"
   },
   {
      "creators" : [
         {
            "id" : "",
            "institution" : "Imperial College London",
            "name" : {
               "family" : "Sirico",
               "given" : "Marianna"
            },
            "orcid" : null
         },
         {
            "id" : "ada43@bath.ac.uk",
            "institution" : "Department of Life Sciences",
            "name" : {
               "family" : "D'Angelo",
               "given" : "Alberto"
            },
            "orcid" : "0000-0001-8417-9172"
         },
         {
            "id" : "",
            "institution" : null,
            "name" : {
               "family" : "Gianni",
               "given" : "Caterina"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : null,
            "name" : {
               "family" : "Casadei",
               "given" : "Chiara"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : null,
            "name" : {
               "family" : "Palleschi",
               "given" : "Michela"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : null,
            "name" : {
               "family" : "De Giorgi",
               "given" : "Ugo"
            },
            "orcid" : null
         }
      ],
      "date" : "2023-01-19",
      "date_type" : "published",
      "issn" : "2072-6694",
      "language" : "english",
      "official_url" : "https://researchportal.bath.ac.uk/en/publications/current-state-and-future-challenges-for-pi3k-inhibitors-in-cancer",
      "publisher" : "MDPI",
      "title" : "Current state and future challenges for PI3K inhibitors in cancer therapy",
      "type" : "article"
   },
   {
      "creators" : [
         {
            "id" : "xt275@bath.ac.uk",
            "institution" : "Department of Computer Science",
            "name" : {
               "family" : "Tian",
               "given" : "Xi"
            },
            "orcid" : null
         },
         {
            "id" : "Y.Yang2@bath.ac.uk",
            "institution" : "Department of Computer Science",
            "name" : {
               "family" : "Yang",
               "given" : "Yongliang"
            },
            "orcid" : "0000-0002-8071-5756"
         },
         {
            "id" : "",
            "institution" : "University of Adelaide",
            "name" : {
               "family" : "Wu",
               "given" : "Qi "
            },
            "orcid" : null
         }
      ],
      "date" : "2022-10-26",
      "date_type" : "published",
      "issn" : "2096-0433",
      "language" : "english",
      "official_url" : "https://researchportal.bath.ac.uk/en/publications/script-to-storyboard-a-new-contextual-retrieval-dataset-and-bench",
      "publisher" : "Tsinghua University Press",
      "title" : "Script-to-Storyboard: A New Contextual Retrieval Dataset and Benchmark",
      "type" : "article"
   },
   {
      "creators" : [
         {
            "id" : "",
            "institution" : "Tsinghua University",
            "name" : {
               "family" : "Xu",
               "given" : "Qun-Ce"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "Tsinghua University",
            "name" : {
               "family" : "Mu",
               "given" : "Tai-Jiang"
            },
            "orcid" : null
         },
         {
            "id" : "Y.Yang2@bath.ac.uk",
            "institution" : "Department of Computer Science",
            "name" : {
               "family" : "Yang",
               "given" : "Yongliang"
            },
            "orcid" : "0000-0002-8071-5756"
         }
      ],
      "date" : "2022-11-01",
      "date_type" : "published",
      "issn" : "2096-0433",
      "language" : "english",
      "official_url" : "https://researchportal.bath.ac.uk/en/publications/a-survey-of-deep-learning-based-3d-shape-generation",
      "publisher" : "Tsinghua University Press",
      "title" : "A Survey of Deep Learning-based 3D Shape Generation",
      "type" : "article"
   },
   {
      "creators" : [
         {
            "id" : "",
            "institution" : "Xidian University",
            "name" : {
               "family" : "Li",
               "given" : "Yi-Fan"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "Xidian University",
            "name" : {
               "family" : "Ji",
               "given" : "Hong-Bing"
            },
            "orcid" : null
         },
         {
            "id" : "xc841@bath.ac.uk",
            "institution" : "Artificial Intelligence",
            "name" : {
               "family" : "Chen",
               "given" : "Xi"
            },
            "orcid" : "0000-0002-3577-3308"
         },
         {
            "id" : "",
            "institution" : "Cardiff University",
            "name" : {
               "family" : "Lai",
               "given" : "Yu-Kun"
            },
            "orcid" : null
         },
         {
            "id" : "Y.Yang2@bath.ac.uk",
            "institution" : "Department of Computer Science",
            "name" : {
               "family" : "Yang",
               "given" : "Yongliang"
            },
            "orcid" : "0000-0002-8071-5756"
         }
      ],
      "date" : "2022-11-10",
      "date_type" : "published",
      "issn" : "1077-3142",
      "language" : "english",
      "official_url" : "https://researchportal.bath.ac.uk/en/publications/multi-object-tracking-with-robust-object-regression-and-associati",
      "publisher" : "Elsevier Academic Press Inc",
      "title" : "Multi-object Tracking with Robust Object Regression and Association",
      "type" : "article"
   },
   {
      "abstract" : "Nina T Rogers and colleagues investigate changes in the levels of obesity in children aged 4-5 years and 10-11 years, 19 months after the implementation of UK soft drinks industry levy.",
      "creators" : [
         {
            "id" : "",
            "institution" : null,
            "name" : {
               "family" : "Rogers",
               "given" : "Nina T."
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : null,
            "name" : {
               "family" : "Cummins",
               "given" : "Steven"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : null,
            "name" : {
               "family" : "Forde",
               "given" : "Hannah"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : null,
            "name" : {
               "family" : "Jones",
               "given" : "Catrin P."
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : null,
            "name" : {
               "family" : "Mytton",
               "given" : "Oliver"
            },
            "orcid" : null
         },
         {
            "id" : "H.R.Rutter@bath.ac.uk",
            "institution" : "Department of Social & Policy Sciences",
            "name" : {
               "family" : "Rutter",
               "given" : "Harry"
            },
            "orcid" : "0000-0002-9322-0656"
         },
         {
            "id" : "",
            "institution" : null,
            "name" : {
               "family" : "Sharp",
               "given" : "Stephen J."
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : null,
            "name" : {
               "family" : "Theis",
               "given" : "Dolly"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : null,
            "name" : {
               "family" : "White",
               "given" : "Martin"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : null,
            "name" : {
               "family" : "Adams",
               "given" : "Jean"
            },
            "orcid" : null
         }
      ],
      "date" : "2023-01-26",
      "date_type" : "published",
      "id_number" : "10.1371/journal.pmed.1004160",
      "issn" : "1549-1277",
      "language" : "english",
      "official_url" : "https://researchportal.bath.ac.uk/en/publications/associations-between-trajectories-of-obesity-prevalence-in-englis",
      "publisher" : "Nature Research",
      "title" : "Associations between trajectories of obesity prevalence in English primary school children and the UK soft drinks industry levy: An interrupted time series analysis of surveillance data",
      "type" : "article"
   },
   {
      "abstract" : "We propose and test the idea that trust in the senior leadership team is needed to help overcome the potential widespread decrements to employee wellbeing resulting from the Covid-19 pandemic. Drawing on Conservation of Resources theory, we suggest that psychological capital mediates the relationship between trust in the senior leadership team’s response to Covid-19 and employee wellbeing. We also examine the contextual relevance of line management’s servant leadership alongside country differences (i.e., India vs UK), in reinforcing the importance of trust in fostering psychological capital. We test our model in a time-lagged survey study that follows employed individuals towards the early, middle, and later stages of the first wave of the pandemic, in 2020. Results provide support for our model and indicate potential country differences. Our findings point to the significance of leadership, both at the senior level and at the line management level, in protecting employee wellbeing during crises.",
      "creators" : [
         {
            "id" : "",
            "institution" : "Loughborough University",
            "name" : {
               "family" : "Babu",
               "given" : "Nishat"
            },
            "orcid" : null
         },
         {
            "id" : "lf645@bath.ac.uk",
            "institution" : "Management",
            "name" : {
               "family" : "Fletcher",
               "given" : "Luke"
            },
            "orcid" : "0000-0002-7238-3480"
         },
         {
            "id" : "",
            "institution" : "California State University",
            "name" : {
               "family" : "Pichler",
               "given" : "Shaun"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "Aston University",
            "name" : {
               "family" : "Budhwar",
               "given" : "Pawan"
            },
            "orcid" : null
         }
      ],
      "date" : "2023-01-26",
      "date_type" : "published",
      "issn" : "1740-4754",
      "language" : "english",
      "official_url" : "https://researchportal.bath.ac.uk/en/publications/whats-trust-got-to-do-with-it-examining-trust-in-leadership-psych",
      "publisher" : "Wiley-Blackwell",
      "title" : "What’s Trust Got to Do with It? Examining Trust in Leadership, Psychological Capital, and Employee Wellbeing in a Cross-National Context During COVID-19",
      "type" : "article"
   },
   {
      "creators" : [
         {
            "id" : "",
            "institution" : null,
            "name" : {
               "family" : "Bacon",
               "given" : "Matthew"
            },
            "orcid" : null
         },
         {
            "id" : "jhs77@bath.ac.uk",
            "institution" : "Department of Social & Policy Sciences",
            "name" : {
               "family" : "Spicer",
               "given" : "Jack"
            },
            "orcid" : null
         }
      ],
      "date" : "2023-01-01",
      "date_type" : "published",
      "id_number" : "10.4234/9781003154136",
      "isbn" : "9781003154136",
      "language" : "english",
      "official_url" : "https://researchportal.bath.ac.uk/en/publications/drug-law-enforcement-policing-and-harm-reduction-ending-the-stale",
      "publisher" : "Routledge",
      "title" : "Drug Law Enforcement, Policing and Harm Reduction: Ending the stalemate",
      "type" : "article"
   },
   {
      "creators" : [
         {
            "id" : "C.Horvath@bath.ac.uk",
            "institution" : "Politics, Languages & International Studies",
            "name" : {
               "family" : "Horvath",
               "given" : "Christina"
            },
            "orcid" : "0000-0003-1381-0152"
         },
         {
            "id" : "",
            "institution" : "Politics, Languages & International Studies",
            "name" : {
               "family" : "Maestri",
               "given" : "Eliana"
            },
            "orcid" : null
         }
      ],
      "date" : "2022-10-02",
      "date_type" : "published",
      "id_number" : "10.1080/02639904.2022.2133460",
      "issn" : "0263-9904",
      "language" : "english",
      "official_url" : "https://researchportal.bath.ac.uk/en/publications/female-filiations-a-festschrift-for-adalgisa-giorgio-romance-stud",
      "publisher" : "Taylor and Francis",
      "title" : "Female Filiations: A Festschrift for Adalgisa Giorgio: Romance Studies",
      "type" : "article"
   },
   {
      "abstract" : "As an important anticancer drug, chlormethine has been used for more than 70 years. Owing to its good efficacy and adaptable structure, chlormethine has been integrated with trackable prodrugs, for the investigation of drug control and tumor targeting. Given the increasing importance of precision medicine, with this review we collate the structure–activity and trackable strategies used for chlormethine-based prodrugs: 1) Small molecule prodrugs: structural transformation of closed spiropyran (SP) to zwitterionic merocyanin (MC), intramolecular charge transfer (ICT), fluorescence resonance energy transfer (FRET) and excited-state intramolecular proton transfer (ESIPT) can enable the fluorescence monitoring or quantification of chlormethine release; 2) Polymer prodrugs: using a conjugated backbone or incorporating fluorophores into side chains, polymers can regulate the emission (π-π interactions or aggregation-induced emission (AIE) mechanisms) and control the release of chlormethine; 3) Nanosystem prodrugs: drug release visualized by the triggered rupture, deformation or degradation of the nanocarrier; 4) Chlormethine-based fluorescent probes: the chlormethine moiety can enable mitochondrial DNA or tumor cells targeting, thereby providing probes for subcellular-labelling. 5) Multifunctional fluorescence prodrugs: modification of chlormethine with fluorescent photodynamic therapeutic (PDT) or photothermal therapeutic (PTT) agents, can achieve visible multimodal therapy, involving chemotherapy CT-PDT, CT-PTT and CT-PDT-PTT. These strategies have enabled the development of fluorescent prodrugs using chlormethine, and these approaches will be covered in this review. We envision that such structure–activity relationships will be particularly important for the future development of anticancer drugs suitable for precision medicine.",
      "creators" : [
         {
            "id" : "",
            "institution" : "Hubei University of Science and Technology",
            "name" : {
               "family" : "Jin",
               "given" : "Wenfang"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "Hubei University of Science and Technology",
            "name" : {
               "family" : "Fan",
               "given" : "Baolei"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "Hubei University of Science and Technology",
            "name" : {
               "family" : "Qin",
               "given" : "Xinrui"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "Shaanxi University of Science and Technology",
            "name" : {
               "family" : "Liu",
               "given" : "Yuxia"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "Michigan State University",
            "name" : {
               "family" : "Qian",
               "given" : "Chunqi"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "Shandong Normal University",
            "name" : {
               "family" : "Tang",
               "given" : "Bo"
            },
            "orcid" : null
         },
         {
            "id" : "T.D.James@bath.ac.uk",
            "institution" : "Department of Chemistry",
            "name" : {
               "family" : "James",
               "given" : "Tony D."
            },
            "orcid" : "0000-0002-4095-2191"
         },
         {
            "id" : "",
            "institution" : "Shaanxi University of Science and Technology",
            "name" : {
               "family" : "Chen",
               "given" : "Guang"
            },
            "orcid" : null
         }
      ],
      "date" : "2023-04-30",
      "date_type" : "published",
      "id_number" : "10.1016/j.ccr.2022.214999",
      "issn" : "0010-8545",
      "language" : "english",
      "official_url" : "https://researchportal.bath.ac.uk/en/publications/structure-activity-of-chlormethine-fluorescent-prodrugs-witnessin",
      "publisher" : "Pergamon/Elsevier Science",
      "title" : "Structure-activity of chlormethine fluorescent prodrugs: Witnessing the development of trackable drug delivery",
      "type" : "article"
   },
   {
      "abstract" : "With the advent of immunotherapies, the field of cancer therapy has been revived with new hope, especially for cancers with dismal prognoses, such as the glioblastoma multiforme (GBM). Currently, immunotherapies should potentiate the host’s own antitumor immune response against cancer cells, but it has been documented that they are effective only in small subsets of patients. Therefore, accurate predictors of response are urgently needed to identify who will benefit from immune-modulatory therapies. Brain tumors are challenging in terms of treatments. The immune response in the brain is highly regulated, and the immune microenvironment in brain metastases is active with a high density of tumor-infiltrating lymphocytes (TILs, CD3+ T cells) in certain patients and, therefore, may serve as a potential treatment target. In our study, we performed immunohistochemistry for CD3 and PD-L1 along the routine assessment of the O6-methylguanine-methyltransferase (MGMT) promoter methylation status and the IDH1 and 2 status in a single center cohort of 69 patients with GBM (58 primary tumors and 11 recurrences) who underwent standard multimodal therapies (surgery/radiotherapy/adjuvant temozolamide). We analyzed the association of PD-L1 tumor expression and TILs with overall survival (OS). The PD-L1 expression was observed in 25 of 58 (43%) newly diagnosed primary glioblastoma specimens. The sparse-to-moderate density of TILs, identified with CD3+ expression, was found in 48 of 58 (83%) specimens. Neither PD-L1 expression nor TILs were associated with overall survival. In conclusion, TILs and/or PD-L1 expression are detectable in the majority of glioblastoma samples, and even if they slightly relate to the outcome, they do not show a statistically significant correlation.",
      "creators" : [
         {
            "id" : "",
            "institution" : null,
            "name" : {
               "family" : "Sobhani",
               "given" : "Navid"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : null,
            "name" : {
               "family" : "Bouchè",
               "given" : "Victoria"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : null,
            "name" : {
               "family" : "Aldegheri",
               "given" : "Giovanni"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : null,
            "name" : {
               "family" : "Rocca",
               "given" : "Andrea"
            },
            "orcid" : null
         },
         {
            "id" : "ada43@bath.ac.uk",
            "institution" : "Department of Life Sciences",
            "name" : {
               "family" : "D’angelo",
               "given" : "Alberto"
            },
            "orcid" : "0000-0001-8417-9172"
         },
         {
            "id" : "",
            "institution" : null,
            "name" : {
               "family" : "Giudici",
               "given" : "Fabiola"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : null,
            "name" : {
               "family" : "Bottin",
               "given" : "Cristina"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : null,
            "name" : {
               "family" : "Donofrio",
               "given" : "Carmine Antonio"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : null,
            "name" : {
               "family" : "Pinamonti",
               "given" : "Maurizio"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : null,
            "name" : {
               "family" : "Ferrari",
               "given" : "Benvenuto"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : null,
            "name" : {
               "family" : "Panni",
               "given" : "Stefano"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : null,
            "name" : {
               "family" : "Cominetti",
               "given" : "Marika"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : null,
            "name" : {
               "family" : "Aliaga",
               "given" : "Jahard"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : null,
            "name" : {
               "family" : "Ungari",
               "given" : "Marco"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : null,
            "name" : {
               "family" : "Fioravanti",
               "given" : "Antonio"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : null,
            "name" : {
               "family" : "Zanconati",
               "given" : "Fabrizio"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : null,
            "name" : {
               "family" : "Generali",
               "given" : "Daniele"
            },
            "orcid" : null
         }
      ],
      "date" : "2023-01-22",
      "date_type" : "published",
      "id_number" : "10.3390/biomedicines11020311",
      "language" : "english",
      "official_url" : "https://researchportal.bath.ac.uk/en/publications/analysis-of-pd-l1-and-cd3-expression-in-glioblastoma-patients-and",
      "publisher" : "MDPI",
      "title" : "Analysis of PD-L1 and CD3 Expression in Glioblastoma Patients and Correlation with Outcome: A Single Center Report",
      "type" : "article"
   },
   {
      "abstract" : "Epigenetic modifications are indispensable for regulating gene bodies and TE silencing. DECREASE IN DNA METHYLATION 1 (DDM1) is a chromatin remodeller involved in histone modifications and DNA methylation. Apart from maintaining the epigenome, DDM1 also maintains key plant traits such as flowering time and heterosis. The role of DDM1 in epigenetic regulation is best characterised in plants, especially arabidopsis, rice, maize and tomato. The epigenetic changes induced by DDM1 establish the stable inheritance of many plant traits for at least eight generations, yet DDM1 does not methylate protein-coding genes. The DDM1 TE silencing mechanism is distinct and has evolved independently of other silencing pathways. Unlike the RNA-directed DNA Methylation (RdDM) pathway, DDM1 does not depend on siRNAs to enforce the heterochromatic state of TEs. Here, we review DDM1 TE silencing activity in the RdDM and non-RdDM contexts. The DDM1 TE silencing machinery is strongly associated with the histone linker H1 and histone H2A.W. While the linker histone H1 excludes the RdDM factors from methylating the heterochromatin, the histone H2A.W variant prevents TE mobility. The DDM1-H2A.W strategy alone silences nearly all the mobile TEs in the arabidopsis genome. Thus, the DDM1-directed TE silencing essentially preserves heterochromatic features and abolishes mobile threats to genome stability.",
      "creators" : [
         {
            "id" : "",
            "institution" : null,
            "name" : {
               "family" : "Akinmusola",
               "given" : "Ruth Y."
            },
            "orcid" : null
         },
         {
            "id" : "caw38@bath.ac.uk",
            "institution" : "Department of Life Sciences",
            "name" : {
               "family" : "Wilkins",
               "given" : "Catherine-axa"
            },
            "orcid" : null
         },
         {
            "id" : "J.Doughty@bath.ac.uk",
            "institution" : "Department of Life Sciences",
            "name" : {
               "family" : "Doughty",
               "given" : "James"
            },
            "orcid" : null
         }
      ],
      "date" : "2023-01-18",
      "date_type" : "published",
      "id_number" : "10.3390/plants12030437",
      "language" : "english",
      "official_url" : "https://researchportal.bath.ac.uk/en/publications/ddm1-mediated-te-silencing-in-plants",
      "publisher" : "MDPI",
      "title" : "DDM1-Mediated TE Silencing in Plants",
      "type" : "article"
   },
   {
      "abstract" : "There are substantive theoretical questions about whether personal values affect romantic relationship functioning. The current research tested the association between personal values and romantic relationship quality, while considering potential mediating mechanisms related to pro-relational attitudes, communal strength, intrinsic relationship motivation, and entitlement. Across five studies using different measures of value priorities, we found that the endorsement of self-transcendence values (i.e., benevolence, universalism) was related to higher romantic relationship quality. The findings provided support for the mediating roles of pro-relational attitudes, communal strength, and intrinsic relationship motivation. Lastly, a dyadic analysis in our fifth study showed that self-transcendence values mostly influence a person’s own relationship quality, but not that of their partner. These findings provide the first evidence that personal values are important variables in romantic relationship functioning, while helping to map the mechanisms through which this role occurs.",
      "creators" : [
         {
            "id" : "G.R.Maio@bath.ac.uk",
            "institution" : "Department of Psychology",
            "name" : {
               "family" : "Maio",
               "given" : "Gregory"
            },
            "orcid" : "0000-0001-5408-5829"
         }
      ],
      "date" : "2023-01-24",
      "date_type" : "published",
      "issn" : "0146-1672",
      "language" : "english",
      "official_url" : "https://researchportal.bath.ac.uk/en/publications/values-in-romantic-relationships",
      "publisher" : "Sage Publications",
      "title" : "Values in Romantic Relationships",
      "type" : "article"
   },
   {
      "creators" : [
         {
            "id" : "gbp25@bath.ac.uk",
            "institution" : "Department of Social & Policy Sciences",
            "name" : {
               "family" : "Barkham",
               "given" : "Georgie"
            },
            "orcid" : null
         }
      ],
      "date" : "2022-12-01",
      "date_type" : "published",
      "language" : "english",
      "official_url" : "https://researchportal.bath.ac.uk/en/publications/what-doesnt-kill-you-makes-you-stronger-new-insights-on-rationale",
      "title" : "‘What doesn’t kill you makes you stronger’: New insights on rationale, risk, and reward of the steroid economy in prison",
      "type" : "article"
   },
   {
      "abstract" : "Aluminum waste-can management in Malaysia has recently become a serious environmental and public health issue, particularly in metropolitan areas. This has prompted the need to valorize these waste-cans into value-added products using the most economical and environmentally friendly techniques. In this study, the sol-gel technique was used to synthesize high-quality alumina from the aluminum waste-cans collected. From this method, the observed peaks of the synthesized alumina were identified as diaspore (α-AlO(OH)), boehmite (γ-AlO(OH)), aluminum oxide, or gamma-alumina (γ-Al\n 2O\n 3) crystalline structure and corundum. The morphological configuration, microstructure, and functional group properties of the synthesized alumina were evaluated. All the synthesized alumina exhibited a non-spherical shape and appeared to have hexagonal-like shape particles. Moreover, the XRD patterns of the synthesized alumina AL-6-30 and AL-12-30 exhibited a small angle (1-10°) with no XRD peak, which indicated a mesoporous pore structure with no long-range order. The overall results of γ-alumina synthesized from the aluminum waste-cans showed an optimal condition in producing a highly structured γ-alumina with excellent surface-area characteristics. The synthesized alumina exhibited stronger and highly crystalline functional characteristics almost comparable with the commercially available brands on the market.\n ",
      "creators" : [
         {
            "id" : "",
            "institution" : "Imperial College London",
            "name" : {
               "family" : "Bin Mokaizh",
               "given" : "Aiman A"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "Imperial College London",
            "name" : {
               "family" : "Shariffuddin",
               "given" : "Jun Haslinda"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "Universidade de Brasilia",
            "name" : {
               "family" : "Baarimah",
               "given" : "Abdullah O"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "King Fahd University of Petroleum and Minerals",
            "name" : {
               "family" : "Al-Fakih",
               "given" : "Amin"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "Future University in Egypt",
            "name" : {
               "family" : "Mohamed",
               "given" : "Abdullah"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "Hadhramout University",
            "name" : {
               "family" : "Baarimah",
               "given" : "Salem O"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "Vrije Universiteit Amsterdam",
            "name" : {
               "family" : "Al-Mekhlafi",
               "given" : "Al-Baraa Abdulrahman"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "University of Bath",
            "name" : {
               "family" : "Alenezi",
               "given" : "Hamoud"
            },
            "orcid" : null
         },
         {
            "id" : "oao94@bath.ac.uk",
            "institution" : "Department of Chemical Engineering",
            "name" : {
               "family" : "Olalere",
               "given" : "Olusegun Abayomi"
            },
            "orcid" : "0000-0002-4382-7281"
         },
         {
            "id" : "",
            "institution" : "University of Padua",
            "name" : {
               "family" : "Saeed",
               "given" : "Anwar Ameen Hezam"
            },
            "orcid" : null
         }
      ],
      "date" : "2022-04-22",
      "date_type" : "published",
      "id_number" : "10.3390/ma15093046",
      "issn" : "1996-1944",
      "language" : "english",
      "official_url" : "https://researchportal.bath.ac.uk/en/publications/elucidating-the-effects-of-reaction-time-on-the-physicochemical-c",
      "publisher" : "MDPI",
      "title" : "Elucidating the Effects of Reaction Time on the Physicochemical Characterization of Valorized Synthesized Alumina",
      "type" : "article"
   },
   {
      "abstract" : "The use of natural ingredients for managing diabetes is becoming more popular in recent times due to the several adverse effects associated with synthetic antidiabetic medications. In this study, we investigated the in vitro antidiabetic potential (through inhibition of α-glucosidase (AG) and α-amylase (AA)) of hydrolysates from lupin proteins pretreated with ultrasound and hydrolyzed using alcalase (ACT) and flavourzyme (FCT). We further fractionated ACT and FCT into three molecular weight fractions. Unfractionated ACT and FCT showed significantly ( \n p < 0.05) higher AG (IC \n 50 value = 1.65 mg/mL and 1.91 mg/mL) and AA (IC\n 50 value = 1.66 mg/mL and 1.98 mg/mL) inhibitory activities than their ultrafiltrated fractions, where lower IC\n 50 values indicate higher inhibitory activities. Then, ACT and FCT were subjected to peptide sequencing using LC-MS-QTOF to identify the potential AG and AA inhibitors. Molecular docking was performed on peptides with the highest number of hotspots and PeptideRanker score to study their interactions with AG and AA enzymes. Among the peptides identified, SPRRF, FE, and RR were predicted to be the most active peptides against AG, while AA inhibitors were predicted to be RPR, PPGIP, and LRP. Overall, hydrolysates prepared from lupin proteins using alcalase and flavourzyme may be useful in formulating functional food for managing diabetics.\n ",
      "creators" : [
         {
            "id" : "",
            "institution" : "RMIT University",
            "name" : {
               "family" : "Fadimu",
               "given" : "Gbemisola J"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "RMIT University",
            "name" : {
               "family" : "Farahnaky",
               "given" : "Asgar"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "RMIT University",
            "name" : {
               "family" : "Gill",
               "given" : "Harsharn"
            },
            "orcid" : null
         },
         {
            "id" : "oao94@bath.ac.uk",
            "institution" : "Department of Chemical Engineering",
            "name" : {
               "family" : "Olalere",
               "given" : "Olusegun A"
            },
            "orcid" : "0000-0002-4382-7281"
         },
         {
            "id" : "",
            "institution" : "University Innovation Incubator Building",
            "name" : {
               "family" : "Gan",
               "given" : "Chee-Yuen"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "RMIT University",
            "name" : {
               "family" : "Truong",
               "given" : "Tuyen"
            },
            "orcid" : null
         }
      ],
      "date" : "2022-10-26",
      "date_type" : "published",
      "id_number" : "10.3390/foods11213375",
      "issn" : "2304-8158",
      "language" : "english",
      "official_url" : "https://researchportal.bath.ac.uk/en/publications/in-silico-analysis-and-antidiabetic-effect-of-%CE%B1-amylase-and-%CE%B1-glu",
      "publisher" : "MDPI",
      "title" : "In-Silico Analysis and Antidiabetic Effect of α-Amylase and α-Glucosidase Inhibitory Peptides from Lupin Protein Hydrolysate: Enzyme-Peptide Interaction Study Using Molecular Docking Approach",
      "type" : "article"
   },
   {
      "abstract" : "In this study, the combination of parameters required for optimal extraction of anti-oxidative components from the Chinese lotus (CLR) and Malaysian lotus (MLR) roots were carefully investigated. Box-Behnken design was employed to optimize the pH (X\n 1: 2-3), extraction time (X\n 2: 0.5-1.5 h) and solvent-to-sample ratio (X\n 3: 20-40 mL/g) to obtain a high flavonoid yield with high % DPPH\n sc free radical scavenging and Ferric-reducing power assay (FRAP). The analysis of variance clearly showed the significant contribution of quadratic model for all responses. The optimal conditions for both Chinese lotus (CLR) and Malaysian lotus (MLR) roots were obtained as: CLR: X\n 1 = 2.5; X\n 2 = 0.5 h; X\n 3 = 40 mL/g; MLR: X\n 1 = 2.4; X\n 2 = 0.5 h; X\n 3 = 40 mL/g. These optimum conditions gave (a) Total flavonoid content (TFC) of 0.599 mg PCE/g sample and 0.549 mg PCE/g sample, respectively; (b) % DPPH\n sc of 48.36% and 29.11%, respectively; (c) FRAP value of 2.07 mM FeSO\n 4 and 1.89 mM FeSO\n 4, respectively. A close agreement between predicted and experimental values was found. The result obtained succinctly revealed that the Chinese lotus exhibited higher antioxidant and total flavonoid content when compared with the Malaysia lotus root at optimum extraction condition.\n ",
      "creators" : [
         {
            "id" : "",
            "institution" : "Tunku Abdul Rahman University College",
            "name" : {
               "family" : "Tan",
               "given" : "Sze-Jack"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "School of Industrial Technology",
            "name" : {
               "family" : "Lee",
               "given" : "Chee-Keong"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "University Innovation Incubator Building",
            "name" : {
               "family" : "Gan",
               "given" : "Chee-Yuen"
            },
            "orcid" : null
         },
         {
            "id" : "oao94@bath.ac.uk",
            "institution" : "Department of Chemical Engineering",
            "name" : {
               "family" : "Olalere",
               "given" : "Olusegun Abayomi"
            },
            "orcid" : "0000-0002-4382-7281"
         }
      ],
      "date" : "2021-04-01",
      "date_type" : "published",
      "id_number" : "10.3390/molecules26072014",
      "issn" : "1420-3049",
      "language" : "english",
      "official_url" : "https://researchportal.bath.ac.uk/en/publications/statistical-optimization-of-flavonoid-and-antioxidant-recovery-fr",
      "publisher" : "MDPI",
      "title" : "Statistical Optimization of Flavonoid and Antioxidant Recovery from Macerated Chinese and Malaysian Lotus Root (\n        Nelumbo nucifera) Using Response Surface Methodology.",
      "type" : "article"
   },
   {
      "abstract" : "INTRODUCTION: The quality characteristics and stability of phenolic by-products from Cola nitida wastes are critical factors for drug formulation and food nutraceutical applications.OBJECTIVES: In this study, the effect of electromagnetic-based microwave-reflux extraction on the total phenolic content, antioxidant capacity, morphological characteristics, physisorption and chromatographic phenolic profiles were successfully investigated. These physicochemical analyses are often employed in the standardisation of dried herbal and food nutraceutical products.MATERIAL AND METHODS: In this study, the electromagnetic-based extraction process was optimised using the Box-Behnken design. The oleoresin bio-products were subsequently characterised to determine the total phenolic content, morphological and microstructural degradation. These analyses were conducted to elucidate the effect of the microwave heating on the C. nitida pod powder.RESULTS: From the predicted response, the optimal percentage yield was achieved at 26.20% under 5.39 min of irradiation time, 440 W microwave power and oven temperature of 55°C. Moreover, the rapid estimation of the phenolic content and antioxidant capacity were recorded at 124.84 ± 0.064 mg gallic acid equivalent (GAE)/g dry weight (d.w.) and 6.93 ± 0.34 μg/mL, respectively. The physicochemical characterisation results from the Fourier-transform infrared spectroscopy, field emission scanning electron microscopy and physisorption analyses showed remarkable changes in the micro-surface area (13.66%) characteristics.CONCLUSION: The recorded optimal conditions established a basis for future scale-up of microwave extraction parameters with a potential for maximum yield. The physiochemical characterisation revealed the functional characteristics of C. nitida and their tolerance to microwave heating.",
      "creators" : [
         {
            "id" : "oao94@bath.ac.uk",
            "institution" : "Department of Chemical Engineering",
            "name" : {
               "family" : "Olalere",
               "given" : "Olusegun Abayomi"
            },
            "orcid" : "0000-0002-4382-7281"
         },
         {
            "id" : "",
            "institution" : "University Innovation Incubator Building",
            "name" : {
               "family" : "Gan",
               "given" : "Chee-Yuen"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "University of Huddersfield",
            "name" : {
               "family" : "Akintomiwa",
               "given" : "Olumide Esan"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "Michael Okpara University of Agriculture",
            "name" : {
               "family" : "Adeyi",
               "given" : "Oladayo"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "Forestry Research Institute of Nigeria",
            "name" : {
               "family" : "Adeyi",
               "given" : "Abiola"
            },
            "orcid" : null
         }
      ],
      "date" : "2021-09-01",
      "date_type" : "published",
      "id_number" : "10.1002/pca.3030",
      "issn" : "0958-0344",
      "language" : "english",
      "official_url" : "https://researchportal.bath.ac.uk/en/publications/optimisation-of-microwave-assisted-extraction-and-functional-eluc",
      "publisher" : "Wiley",
      "title" : "Optimisation of microwave-assisted extraction and functional elucidation of bioactive compounds from Cola nitida pod",
      "type" : "article"
   },
   {
      "abstract" : "ZnO is a widely studied photocatalyst, but practical use is hindered by its low resistance to photocorrosion in water, which leads to metal leaching and loss of performance over time. In this work, highly porous and mechanically stable ZnO foams, called MolFoams, were doped by adding 1% or 2% Co, Ni or Cu salts to the starting Zn salt, followed by air insufflation during a sol–gel rection and sintering. The resulting doped foams showed a major increase in stability, with a 60–85% reduction in Zn2+ leaching after irradiation, albeit with a reduction in photocatalytic activity. A systematic analysis using XRD, Raman, XPS and XANES allowed for the identification of dopant species in the foams revealing the presence of Co3O4, NiO and Cu2O within the ZnO lattice with doping leading to a reduced band gap and significant increases in the resistance to photocorrosion of ZnO while identifying the cause of the reduction in photocatalytic activity to be shifting of the band edge positions. These results provide a pathway to significantly reduce the photocorrosion of ZnO in water, with further work required to maintain the photocatalytic activity of undoped ZnO.",
      "creators" : [
         {
            "id" : "zw799@bath.ac.uk",
            "institution" : "Department of Chemical Engineering",
            "name" : {
               "family" : "Warren",
               "given" : "Zachary"
            },
            "orcid" : null
         },
         {
            "id" : "D.Mattia@bath.ac.uk",
            "institution" : "Faculty of Engineering and Design",
            "name" : {
               "family" : "Mattia",
               "given" : "Davide"
            },
            "orcid" : "0000-0002-7679-4105"
         },
         {
            "id" : "J.H.Wenk@bath.ac.uk",
            "institution" : "Centre for Sustainable and Circular Technologies (CSCT)",
            "name" : {
               "family" : "Wenk",
               "given" : "Jannis"
            },
            "orcid" : "0000-0001-9182-0407"
         }
      ],
      "date" : "2023-01-01",
      "date_type" : "published",
      "id_number" : "10.1039/d2ra06730g",
      "issn" : "2046-2069",
      "language" : "english",
      "official_url" : "https://researchportal.bath.ac.uk/en/publications/increased-photocorrosion-resistance-of-zno-foams-via-transition-m",
      "publisher" : "Royal Society of Chemistry",
      "title" : "Increased photocorrosion resistance of ZnO foams via transition metal doping",
      "type" : "article"
   },
   {
      "abstract" : "People differ greatly in their attitudes towards well-evidenced science. What characterises this variation? Here, we consider this issue in the context of genetics and allied sciences. While most prior research has focused on the relationship between attitude to science and what people know about it, recent evidence suggests that individuals with strongly negative attitudes towards specific genetic technologies (genetic modification (GM) technology and vaccines) commonly do not objectively understand the science, but, importantly, believe that they do. Here, using data from a probability survey of United Kingdom adults, we extend this prior work in 2 regards. First, we ask whether people with more extreme attitudes, be they positive or negative, are more likely to believe that they understand the science. Second, as negativity to genetics is commonly framed around issues particular to specific technologies, we ask whether attitudinal trends are contingent on specification of technology. We find (1) that individuals with strongly positive or negative attitudes towards genetics more strongly believe that they well understand the science; but (2) only for those most positive to the science is this self-confidence warranted; and (3) these effects are not contingent on specification of any particular technologies. These results suggest a potentially general model to explain why people differ in their degree of acceptance or rejection of science, this being that the more someone believes they understand the science, the more confident they will be in their acceptance or rejection of it. While there are more technology nonspecific opponents who also oppose GM technology than expected by chance, most GM opponents fit a different demographic. For the most part, opposition to GM appears not to reflect a smokescreen concealing a broader underlying negativity.",
      "creators" : [
         {
            "id" : "L.D.Hurst@bath.ac.uk",
            "institution" : "Department of Life Sciences",
            "name" : {
               "family" : "Hurst",
               "given" : "Laurence"
            },
            "orcid" : "0000-0002-1002-1054"
         }
      ],
      "date" : "2023-01-24",
      "date_type" : "published",
      "id_number" : "10.1371/journal.pbio.3001915",
      "issn" : "1545-7885",
      "language" : "english",
      "official_url" : "https://researchportal.bath.ac.uk/en/publications/people-with-more-extreme-attitudes-towards-science-have-self-conf",
      "publisher" : "Public Library of Science (PLOS)",
      "title" : "People with more extreme attitudes towards science have self-confidence in their understanding of science, even if this is not justified",
      "type" : "article"
   },
   {
      "creators" : [
         {
            "id" : "J.Thomson@bath.ac.uk",
            "institution" : "Politics, Languages & International Studies",
            "name" : {
               "family" : "Thomson",
               "given" : "Jennifer"
            },
            "orcid" : null
         },
         {
            "id" : "S.Whiting@bath.ac.uk",
            "institution" : "Centre for Qualitative Research",
            "name" : {
               "family" : "Whiting",
               "given" : "Sophie"
            },
            "orcid" : null
         }
      ],
      "date" : "2022-08",
      "date_type" : "published",
      "language" : "english",
      "official_url" : "https://researchportal.bath.ac.uk/en/publications/symbolic-and-imaginary-anti-gender-states-engagement-with-the-uns",
      "title" : "'Symbolic' and 'imaginary': anti-gender states' engagement with the UN's Women, Peace and Security agenda",
      "type" : "article"
   },
   {
      "abstract" : "Defatted wheat germ is a viable source of plant-based proteins and this could be attributed to its high protein content. In this study, protein-rich DWG fractions were precipitated from extracts obtained via conventional alkaline and novel DES-microwave extraction techniques. Protein yield, SDS-PAGE protein profile, gelation property, water/oil holding capacities, foaming capacity, emulsifying activity, emulsion stability, as well as protein solubility and digestibility were all succinctly investigated from the protein isolates. The comparative study showed 33.0 ± 0.2% and 12.5 ± 0.01% of protein recovery from DES-microwave and conventional extractions, respectively. Moreover, from the SDS-PAGE results, the DES-microwave-assisted extraction approach was just as effective as the conventional extraction method, with no evidence of protein hydrolysis or degradation. Additionally, the protein fraction extracted through the DES-microwave method exhibited higher water solubility with the formation of firmer gel structure; higher EA (50%); excellent WHC/OHC (3.892 mg H2O/mg sample; 6.410 mg oil/mg sample); good FC (75.9%), and higher D (85.03%). In comparison, the protein fraction from conventional alkaline extraction exhibited a water-holding capacity of 3.496 mg H2O/mg sample, oil holding 6.154 mg oil/mg sample, FC = 25.8%, EC = 25%, D = 78.69%). The enhanced functionalities of the DWG protein revealed DES-microwave-assisted approach as a promising technique for obtaining pure protein concentrate. This is the first study to provide insight into the functionalities of wheat germ protein using novel deep eutectic solvents (DES) via an electromagnetic-based microwaved medium.",
      "creators" : [
         {
            "id" : "oao94@bath.ac.uk",
            "institution" : "Department of Chemical Engineering",
            "name" : {
               "family" : "Olalere",
               "given" : "Olusegun"
            },
            "orcid" : "0000-0002-4382-7281"
         },
         {
            "id" : "",
            "institution" : "Universiti Sains Malaysia",
            "name" : {
               "family" : "Gan",
               "given" : "Chee-Yuen"
            },
            "orcid" : null
         }
      ],
      "date" : "2023-05-31",
      "date_type" : "published",
      "id_number" : "10.1016/j.scp.2023.101002",
      "issn" : "2352-5541",
      "language" : "english",
      "official_url" : "https://researchportal.bath.ac.uk/en/publications/extractability-of-defatted-wheat-germ-protein-and-their-functiona",
      "publisher" : "Elsevier",
      "title" : "Extractability of defatted wheat germ protein and their functionalities in a deep eutectic solvent (DES)-Microwave extraction approach compared to conventional processing",
      "type" : "article"
   },
   {
      "creators" : [
         {
            "id" : "fgg26@bath.ac.uk",
            "institution" : "Department of Chemical Engineering",
            "name" : {
               "family" : "Guler Gencer",
               "given" : "Fatma"
            },
            "orcid" : "0000-0003-4385-1131"
         },
         {
            "id" : "",
            "institution" : "Ankara University",
            "name" : {
               "family" : "Ozcelik",
               "given" : "Filiz"
            },
            "orcid" : null
         }
      ],
      "date" : "2017",
      "date_type" : "published",
      "id_number" : "10.15237/GIDA.GD17060",
      "issn" : "1300-3070",
      "language" : "english",
      "official_url" : "https://researchportal.bath.ac.uk/en/publications/an-adaptation-strategy-to-improve-the-proteolytic-activities-of-l",
      "title" : "AN ADAPTATION STRATEGY TO IMPROVE THE PROTEOLYTIC ACTIVITIES OF LACTIC ACID BACTERIA ISOLATED FROM PICKLES",
      "type" : "article"
   },
   {
      "abstract" : "This work demonstrated the performances of different protic ionic liquids (PILs) with respect to their effects on the pretreatment of cotton stalks at a relatively high biomass loading. Among the investigated PILs, 1-butylimidazolium hydrogen sulfate (HBIMHSO4) employed in the presence of 20% (w/w) water at 15% biomass loading and 120 °C for four hours resulted in significant structural changes in the biomass. The lignin content of the cotton stalks was reduced by 35% and the cellulose content increased from 36% to 55% through HBIMHSO4 pretreatment. Enzymatic hydrolysis of the biomass was enhanced almost 5-fold despite an increase in the biomass crystallinity. Morphological changes in the cotton stalks observed through SEM analysis verified the differences in the composition and enzymatic accessibility of the biomass samples subjected to PIL pretreatment. The results successfully revealed the potential of the PIL, HBIMHSO4 for the valorization of cotton stalks, as a significant industrial crop waste, for the first time in the literature.",
      "creators" : [
         {
            "id" : "",
            "institution" : "Social Sciences University of Ankara",
            "name" : {
               "family" : "Semerci",
               "given" : "Işık"
            },
            "orcid" : null
         },
         {
            "id" : "fgg26@bath.ac.uk",
            "institution" : "Department of Chemical Engineering",
            "name" : {
               "family" : "Güler",
               "given" : "Fatma"
            },
            "orcid" : "0000-0003-4385-1131"
         }
      ],
      "date" : "2018-12-01",
      "date_type" : "published",
      "id_number" : "10.1016/j.indcrop.2018.09.046",
      "issn" : "0926-6690",
      "language" : "english",
      "official_url" : "https://researchportal.bath.ac.uk/en/publications/protic-ionic-liquids-as-effective-agents-for-pretreatment-of-cott",
      "publisher" : "Elsevier",
      "title" : "Protic ionic liquids as effective agents for pretreatment of cotton stalks at high biomass loading",
      "type" : "article"
   },
   {
      "abstract" : "The use of protic ionic liquids (PILs) in biomass processing has attracted significant attention in the recent years due to their synthesis in a relatively cheaper and easier way in comparison with their aprotic counterparts. In this study, PIL, triethylammmonium hydrogen sulfate (TEAHSO4) was explored in terms of its effects on the deconstruction of industrial crop wastes; corn cob, corn husk and wheat bran. Characterization of the pretreated biomass samples via scanning electron microscopy (SEM) and compositional analysis demonstrated structural changes and improvements in the cellulose content of the biomass. TEAHSO4 led to favorable modifications in the composition of wheat bran. It enhanced cellulose content of wheat bran from 40% to 60%, through removal of 67% of the lignin present in the biomass. Pretreated biomass samples were evaluated in terms of their conversion to glucose. At the 24th hour of the enzymatic reaction, cellulose in the pretreated corn cob, corn husk and wheat bran samples were converted into glucose with roughly 85%, 71% and 96% yields, respectively. TEAHSO4 pretreatment enhanced the enzymatic accessibility of wheat bran almost 10-fold. Ionic liquid media recovered following the pretreatments were analyzed for their content regarding the platform chemicals; 5-hydroxymethylfurfural (5- HMF) and levulinic acid (LA). The highest yield for 5-HMF was obtained as 47% in the ionic liquid medium obtained upon TEAHSO4 pretreatment of corn husk. On the other hand, corn cob pretreatment resulted in the highest LA yield which was 93%.",
      "creators" : [
         {
            "id" : "",
            "institution" : "Ankara University",
            "name" : {
               "family" : "Semerci",
               "given" : "Işik"
            },
            "orcid" : null
         },
         {
            "id" : "fgg26@bath.ac.uk",
            "institution" : "Department of Chemical Engineering",
            "name" : {
               "family" : "Güler",
               "given" : "Fatma"
            },
            "orcid" : "0000-0003-4385-1131"
         }
      ],
      "date" : "2019-03-01",
      "date_type" : "published",
      "language" : "english",
      "official_url" : "https://researchportal.bath.ac.uk/en/publications/pretreatment-of-crop-wastes-from-edible-biomass-with-a-protic-ion",
      "publisher" : "Gaza University",
      "title" : "Pretreatment of crop wastes from edible biomass with a protic ionic liquid",
      "type" : "article"
   },
   {
      "abstract" : "In this work, the potential of protic ionic liquid, triethylammonium hydrogen sulfate (TEAHSO4) was shown regarding the pretreatment of the hardwood, hornbeam and softwood, pine at different temperatures and times. TEAHSO4 was effective for lignin extraction and enhancing the enzymatic digestibility of both the biomass. Cellulose content of hornbeam increased to 85% with 87% lignin extraction from the biomass subjected to pretreatment at 150 °C for 3 h which was then readily converted into glucose with 97% yield. On the other hand, pine as a softwood demonstrated more resilience to deconstruction; 76% glucose yield was achieved following the enzymatic hydrolysis of biomass pretreated at 150 °C for 30 min. As put forward in the present work through TEAHSO4 pretreatment, any lignocellulosic feedstock that can be effectively disassembled into cellulose and lignin should be regarded as high value for the production of liquid and gaseous fuels through thermochemical and biochemical routes.",
      "creators" : [
         {
            "id" : "",
            "institution" : "Ankara University",
            "name" : {
               "family" : "Semerci",
               "given" : "Isık"
            },
            "orcid" : null
         },
         {
            "id" : "fgg26@bath.ac.uk",
            "institution" : "Department of Chemical Engineering",
            "name" : {
               "family" : "Güler",
               "given" : "Fatma"
            },
            "orcid" : "0000-0003-4385-1131"
         },
         {
            "id" : "",
            "institution" : "Ankara University",
            "name" : {
               "family" : "Ersan",
               "given" : "Gulsah"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : null,
            "name" : {
               "family" : "Soysal",
               "given" : "Kaan"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : null,
            "name" : {
               "family" : "Ozturk",
               "given" : "Onur"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : null,
            "name" : {
               "family" : "Altinisik",
               "given" : "Hasan"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : null,
            "name" : {
               "family" : "Tirpan",
               "given" : "Sena"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "Ankara University",
            "name" : {
               "family" : "Ozcelik",
               "given" : "Filiz"
            },
            "orcid" : null
         }
      ],
      "date" : "2019-12-31",
      "date_type" : "published",
      "id_number" : "10.1016/j.biteb.2019.100334",
      "issn" : "2589-014X",
      "language" : "english",
      "official_url" : "https://researchportal.bath.ac.uk/en/publications/assessment-of-a-protic-ionic-liquid-with-respect-to-fractionation",
      "publisher" : "Elsevier",
      "title" : "Assessment of a protic ionic liquid with respect to fractionation and changes in the structural features of hardwood and softwood",
      "type" : "article"
   },
   {
      "abstract" : "In this work, protic ionic liquid, 1-methylimidazolium hydrogen sulfate (HMIMHSO4) and gamma-valerolactone (GVL) were explored with respect to their effects on levulinic acid production directly from cotton stalks and pine using the acidic catalyst, CrCl3.6H2O in a hydrothermal reactor. GVL as a biomass-derived solvent resulted in higher yields of levulinic acid compared to HMIMHSO4 which was attributed to the higher lignin depolymerization capacity of the solvent and GVL’s capability for stabilization of the solvated protons. The increasing water content of the media from 10% to 20% enhanced the production and the yields. GVL gave the maximum levulinic acid concentration and yield from pine; 21.4 g/L and 78%, respectively when the reaction was conducted at 180 °C and 10% biomass loading with 20% water and 0.1 M CrCl3.6H2O for 4 h.",
      "creators" : [
         {
            "id" : "",
            "institution" : "Social Sciences University of Ankara",
            "name" : {
               "family" : "Haykir",
               "given" : "Nazife Isik"
            },
            "orcid" : null
         },
         {
            "id" : "fgg26@bath.ac.uk",
            "institution" : "Department of Chemical Engineering",
            "name" : {
               "family" : "Guler",
               "given" : "Fatma"
            },
            "orcid" : "0000-0003-4385-1131"
         }
      ],
      "date" : "2021-12-31",
      "date_type" : "published",
      "id_number" : "10.1080/02773813.2021.1873388",
      "issn" : "0277-3813",
      "language" : "english",
      "official_url" : "https://researchportal.bath.ac.uk/en/publications/levulinic-acid-production-from-wood-with-green-solvents",
      "publisher" : "Taylor and Francis",
      "title" : "Levulinic acid production from wood with green solvents",
      "type" : "article"
   },
   {
      "abstract" : "BACKGROUND: Polypharmacy is associated with poor outcomes in older adults. Targeted deprescribing of anticholinergic and sedative medications may improve health outcomes for frail older adults. Our pharmacist-led deprescribing intervention was a pragmatic two-arm randomized controlled trial stratified by frailty. We compared usual care (control) with the intervention of pharmacists providing deprescribing recommendations to general practitioners.METHODS: Community-based older adults (≥65 years) from two New Zealand district health boards were recruited following a standardized interRAI needs assessment. The Drug Burden Index (DBI) was used to quantify use of sedative and anticholinergic medications for each participant. The trial was stratified into low, medium, and high frailty. We hypothesized that the intervention would increase the proportion of participants with a reduction in DBI ≥ 0.5 within six months.RESULTS: Of 363 participants, 21 (12.7%) in the control group and 21 (12.2%) in the intervention group had a reduction in DBI ≥ 0.5. The difference in the proportion of -0.4% (95%CI: -7.9% to 7.0%) provided no evidence of efficacy for the intervention. Similarly, there was no evidence to suggest the effectiveness of this intervention for participants of any frailty level.CONCLUSIONS: Our pharmacist-led medication review of frail older participants did not reduce the anticholinergic/sedative load within six months. Covid-19 lockdown measures required modification of the intervention. Subgroup analyses pre- and post-lockdown showed no impact on outcomes. Reviewing this and other deprescribing trials through the lens of implementation science may aid an understanding of the contextual determinants preventing or enabling successful deprescribing implementation strategies.",
      "creators" : [
         {
            "id" : "",
            "institution" : "University of Otago",
            "name" : {
               "family" : "Jamieson",
               "given" : "Hamish"
            },
            "orcid" : null
         },
         {
            "id" : "P.Nishtala@bath.ac.uk",
            "institution" : "Centre for Therapeutic Innovation",
            "name" : {
               "family" : "Nishtala",
               "given" : "Prasad S"
            },
            "orcid" : "0000-0002-4155-8540"
         },
         {
            "id" : "",
            "institution" : "University of Otago",
            "name" : {
               "family" : "Bergler",
               "given" : "Hans Ulrich"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "University of Otago",
            "name" : {
               "family" : "Weaver",
               "given" : "Susan K"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "University of Otago",
            "name" : {
               "family" : "Pickering",
               "given" : "John W"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "University of Southern Queensland",
            "name" : {
               "family" : "Ailabouni",
               "given" : "Nagham J"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "University of Otago",
            "name" : {
               "family" : "Abey-Nesbit",
               "given" : "Rebecca"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "Canterbury District Health Board",
            "name" : {
               "family" : "Gullery",
               "given" : "Carolyn"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "Burwood Academy Trust",
            "name" : {
               "family" : "Deely",
               "given" : "Joanne"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "Canterbury District Health Board",
            "name" : {
               "family" : "Gee",
               "given" : "Susan B"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "University of Sydney",
            "name" : {
               "family" : "Hilmer",
               "given" : "Sarah N"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "University of Otago",
            "name" : {
               "family" : "Mangin",
               "given" : "Dee"
            },
            "orcid" : null
         }
      ],
      "date" : "2023-01-24",
      "date_type" : "published",
      "id_number" : "10.1093/gerona/glac249",
      "issn" : "1079-5006",
      "language" : "english",
      "official_url" : "https://researchportal.bath.ac.uk/en/publications/deprescribing-anticholinergic-and-sedative-drugs-to-reduce-polyph",
      "publisher" : "Oxford University Press",
      "title" : "Deprescribing anticholinergic and sedative drugs to reduce polypharmacy in frail older adults living in the community: a randomized controlled trial",
      "type" : "article"
   },
   {
      "abstract" : "Perceptual anomalies can provide insights into underlying pathologies even when they are not the main symptom of many clinical conditions. Complex regional pain syndrome (CRPS) and fibromyalgia are chronic pain conditions associated with changes in the central nervous system, possibly leading to enhanced visual sensitivity. It is unclear whether this occurs more than for people with other types of pain. We examined visual sensitivity elicited by different stimuli and in daily life, through an online study of people with CRPS (n = 57), fibromyalgia (n = 74), other pain (n = 50), and no pain (n = 89). Respondents rated changes in pain, discomfort, or distress from viewing patterns with different spatial frequencies (lower-order visual processing), and reversible figures (bistable images; higher-order visual processing). We assessed visual sensitivity in daily life using the Leiden Visual Sensitivity Scale and Visual Discomfort Scale. Respondents with CRPS or fibromyalgia reported more visual discomfort than pain-related and pain-free controls while viewing striped patterns and a circle, with no effect of spatial frequency. They reported more pain while viewing a nonreversible square, but not reversible figures (Necker Cube, Duck/Rabbit). Finally, they reported more daily visual sensitivity than pain-related and pain-free controls. Suppressing visual cortical activity might benefit people with CRPS or fibromyalgia.",
      "creators" : [
         {
            "id" : "",
            "institution" : "University of Bath",
            "name" : {
               "family" : "Ten Brink",
               "given" : "Antonia F."
            },
            "orcid" : null
         },
         {
            "id" : "J.Bultitude@bath.ac.uk",
            "institution" : "University of Bath",
            "name" : {
               "family" : "Bultitude",
               "given" : "Janet H."
            },
            "orcid" : "0000-0003-4648-6184"
         }
      ],
      "date" : "2022-03-03",
      "date_type" : "published",
      "id_number" : "10.1177/03010066211072641",
      "issn" : "0301-0066",
      "language" : "english",
      "official_url" : "https://researchportal.bath.ac.uk/en/publications/visual-sensitivity-in-complex-regional-pain-syndrome-and-fibromya",
      "publisher" : "Pion Ltd.",
      "title" : "Visual Sensitivity in Complex Regional Pain Syndrome and Fibromyalgia: An Online Study",
      "type" : "article"
   },
   {
      "abstract" : "Background: The prevalence of diabetes is increasing with growing levels of obesity and an aging population. New practical guidelines for diabetes provide an applicable classification. Inconsistent codingof diabetes hampers the use of computerised disease registers for quality improvement, and limits the monitoring of disease trends. Objective: To develop a consensus set of codes that should be used when recording diabetes diagnostic data. Methods: The consensus approach was hierarchical, with a preference for diagnostic/disorder codes, to define each type of diabetes and non-diabetic hyperglycaemia, which were listed as being completely, partially or not readily mapped to available codes. The practical classification divides diabetes into type 1 (T1DM), type 2 (T2DM), genetic, other, unclassified and non-diabetic fasting hyperglycaemia. We mapped the classification to Read version 2, Clinical Terms version 3 and SNOMED CT. Results: T1DM and T2DM were completely mapped to appropriate codes. However, in other areas only partial mapping is possible. Genetics is a fastmoving field and there were considerable gaps in the available labels for genetic conditions; what the classification calls 'other' the coding system labels 'secondary' diabetes. The biggest gap was the lack of a code for diabetes where the type of diabetes was uncertain. Notwithstanding these limitations we were able to develop a consensus list. Conclusions: It is a challenge to develop codes that readily map to contemporary clinical concepts. However, clinicians should adopt the standard recommended codes; and audit the quality of their existing records.",
      "creators" : [
         {
            "id" : "",
            "institution" : "University of Surrey",
            "name" : {
               "family" : "De Lusignan",
               "given" : "Simon"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "University of Surrey",
            "name" : {
               "family" : "Sadek",
               "given" : "Khaled"
            },
            "orcid" : null
         },
         {
            "id" : "him24@bath.ac.uk",
            "institution" : "London School of Hygiene & Tropical Medicine",
            "name" : {
               "family" : "McDonald",
               "given" : "Helen"
            },
            "orcid" : "0000-0003-0576-2015"
         },
         {
            "id" : "",
            "institution" : "University of Nottingham",
            "name" : {
               "family" : "Horsfield",
               "given" : "Pete"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "Academic Foundation Programme",
            "name" : {
               "family" : "Sadek",
               "given" : "Norah Hassan"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : null,
            "name" : {
               "family" : "Tahir",
               "given" : "Aumran"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "University of Surrey",
            "name" : {
               "family" : "Desombre",
               "given" : "Terry"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "University of Leicester",
            "name" : {
               "family" : "Khunti",
               "given" : "Kamlesh"
            },
            "orcid" : null
         }
      ],
      "date" : "2012-02-29",
      "date_type" : "published",
      "issn" : "1476-0320",
      "language" : "english",
      "official_url" : "https://researchportal.bath.ac.uk/en/publications/call-for-consistent-coding-in-diabetes-mellitus-using-the-royal-c",
      "publisher" : "BCS, The Chartered Institute for IT",
      "title" : "Call for consistent coding in diabetes mellitus using the royal college of general practitioners and NHS pragmatic classification of diabetes",
      "type" : "article"
   },
   {
      "abstract" : "Aims: To assess the performance of a range of biomarkers of alcohol consumption in a heavy-drinking population of working-aged Russian men. Design: Cross-sectional study of men originally sampled at random from a population register. Setting: Izhevsk, a Russian city with a population of 650000 people. Participants: A total of 1023 men aged 27-59 years living in Izhevsk who took part in a health check examination in 2008-2009. Measurements: Self-reported alcohol consumption, hazardous drinking behaviours, socio-economic position, anthropometric measurements plus blood levels of alcohol biomarkers [carbohydrate-deficient transferrin (CDT, gamma-glutamyl transferase (GGT), alanine aminotransferase (ALT), aspartate aminotransferase (AST) and mean cell volume of erythrocytes (MCV)] and hepatitis B and C status. Findings: In the year before interview there was a high prevalence of high-risk alcohol consumption indicated by consumption of non-beverage alcohols (5%), problem drinking behaviours (4.4%) and alcohol consumption exceeding an average 40g per day (12.6%). All biomarkers were associated strongly with total beverage alcohol consumption even after adjustment for confounders. CDT performed best as an alcohol biomarker, with a sensitivity of 67% and specificity of 71% for detecting an average consumption of more than 40g per day versus less. For all biomarkers sensitivity was considerably lower than specificity. Hazardous drinking patterns per se were not well detected by any of the biomarkers, all with sensitivity below 60%. Conclusions: In a Russian population with high levels of alcohol consumption, carbohydrate-deficient transferrin (CDT) might be the most sensitive and specific biomarker for detecting ethanol consumption above 40g/day. A biomarker reflecting hazardous drinking patterns has yet to be established.",
      "creators" : [
         {
            "id" : "him24@bath.ac.uk",
            "institution" : "London School of Hygiene & Tropical Medicine",
            "name" : {
               "family" : "Mcdonald",
               "given" : "Helen"
            },
            "orcid" : "0000-0003-0576-2015"
         },
         {
            "id" : "",
            "institution" : "Vavilov Institute of General Genetics, Russian Academy of Sciences",
            "name" : {
               "family" : "Borinskya",
               "given" : "Svetlana"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "Izhevsk State Medical Academy",
            "name" : {
               "family" : "Kiryanov",
               "given" : "Nikolay"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "London School of Hygiene & Tropical Medicine",
            "name" : {
               "family" : "Gil",
               "given" : "Artyom"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "The Karolinska Institute",
            "name" : {
               "family" : "Helander",
               "given" : "Anders"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "London School of Hygiene & Tropical Medicine",
            "name" : {
               "family" : "Leon",
               "given" : "David A."
            },
            "orcid" : null
         }
      ],
      "date" : "2013-05-21",
      "date_type" : "published",
      "id_number" : "10.1111/add.12251",
      "issn" : "0965-2140",
      "language" : "english",
      "official_url" : "https://researchportal.bath.ac.uk/en/publications/comparative-performance-of-biomarkers-of-alcohol-consumption-in-a",
      "publisher" : "Wiley-Blackwell",
      "title" : "Comparative performance of biomarkers of alcohol consumption in a population sample of working-aged men in Russia: The Izhevsk Family Study",
      "type" : "article"
   },
   {
      "abstract" : "Background Hospital admissions for community-acquired infection are increasing rapidly in the United Kingdom, particularly among older individuals, possibly reflecting an increasing prevalence of comorbid conditions such as chronic kidney disease (CKD). This study describes associations between CKD (excluding patients treated by dialysis or transplantation) and community-acquired infection incidence among older people with diabetes mellitus. Study Design Retrospective cohort study using primary care records from the Clinical Practice Research Datalink linked to Hospital Episode Statistics admissions data. Setting & Participants 191,709 patients 65 years or older with diabetes mellitus and no history of renal replacement therapy, United Kingdom, 1997 to 2011. Predictor Estimated glomerular filtration rate (eGFR) and history of proteinuria. Outcomes Incidence of community-acquired lower respiratory tract infections (LRTIs, with pneumonia as a subset) and sepsis, diagnosed in primary or secondary care, excluding hospital admissions from time at risk. Measurements Poisson regression was used to calculate incidence rate ratios (IRRs) adjusted for age, sex, smoking status, comorbid conditions, and characteristics of diabetes. Estimates for associations of eGFR with infection were adjusted for proteinuria, and vice versa. Results Strong graded associations between lower eGFRs and infection were observed. Compared with patients with eGFRs 60 mL/min/1.73 m2, fully adjusted IRRs for pneumonia among those with eGFRs < 15, 15 to 29, 30 to 44, and 45 to 59 mL/min/1.73 m2 were 3.04 (95% CI, 2.42-3.83), 1.73 (95% CI, 1.57-1.92), 1.19 (95% CI, 1.11-1.28), and 0.95 (95% CI, 0.89-1.01), respectively. Associations between lower eGFRs and sepsis were stronger, with fully adjusted IRRs up to 5.56 (95% CI, 3.90-7.94). Those associations with LRTI were weaker but still clinically relevant at up to 1.47 (95% CI, 1.34-1.62). In fully adjusted models, a history of proteinuria remained an independent marker of increased infection risk for LRTI, pneumonia, and sepsis (IRRs of 1.07 [95% CI, 1.05-1.09], 1.26 [95% CI, 1.19-1.33], and 1.33 [95% CI, 1.20-1.47]). Limitations Patients without creatinine results were excluded. Conclusions Strategies to prevent infection among people with CKD are needed.",
      "creators" : [
         {
            "id" : "him24@bath.ac.uk",
            "institution" : "London School of Hygiene & Tropical Medicine",
            "name" : {
               "family" : "McDonald",
               "given" : "Helen I."
            },
            "orcid" : "0000-0003-0576-2015"
         },
         {
            "id" : "",
            "institution" : "London School of Hygiene & Tropical Medicine",
            "name" : {
               "family" : "Thomas",
               "given" : "Sara L."
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "London School of Hygiene & Tropical Medicine",
            "name" : {
               "family" : "Millett",
               "given" : "Elizabeth R.C."
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "London School of Hygiene & Tropical Medicine",
            "name" : {
               "family" : "Nitsch",
               "given" : "Dorothea"
            },
            "orcid" : null
         }
      ],
      "date" : "2015-07-01",
      "date_type" : "published",
      "id_number" : "10.1053/j.ajkd.2014.11.027",
      "issn" : "0272-6386",
      "language" : "english",
      "official_url" : "https://researchportal.bath.ac.uk/en/publications/ckd-and-the-risk-of-acute-community-acquired-infections-among-old",
      "publisher" : "Elsevier",
      "title" : "CKD and the risk of acute, community-acquired infections among older people with diabetes mellitus: A retrospective cohort study using electronic health records",
      "type" : "article"
   },
   {
      "abstract" : "Background. We aimed to examine whether pre-existing impaired estimated glomerular filtration rate (eGFR) and proteinuria were associated with mortality following community-acquired pneumonia or sepsis among people aged ≥65 years with diabetes mellitus, without end-stage renal disease. Methods. Patients were followed up from onset of first community-acquired pneumonia or sepsis episode in a cohort study using large, linked electronic health databases. Follow-up was for up to 90 days, unlimited by hospital discharge. We used generalized linear models with log link, normal distribution and robust standard errors to calculate risk ratios (RRs) for all-cause 28- and 90-day mortality according to two markers of chronic kidney disease: eGFR and proteinuria. Results. All-cause mortality among the 4743 patients with pneumonia was 29.6% after 28 days and 37.4% after 90 days. Among the 1058 patients with sepsis, all-cause 28- and 90-day mortality were 35.6 and 44.2%, respectively. eGFR <30 mL/min/1.73 m2 was a risk marker of higher 28-day mortality for pneumonia (RR 1.27: 95% CI 1.12-1.43) and sepsis (RR 1.32: 95% CI 1.07-1.64), adjusted for age, sex, socio-economic status, smoking status and co-morbidities. Neither moderately impaired eGFR nor proteinuria were associated with short-term mortality following either infection. Conclusions. People with pre-existing low eGFR but not on dialysis are at higher risk of death following pneumonia and sepsis. This association was not explained by existing co-morbidities. These patients need to be carefully monitored to prevent modifiable causes of death.",
      "creators" : [
         {
            "id" : "him24@bath.ac.uk",
            "institution" : "London School of Hygiene & Tropical Medicine",
            "name" : {
               "family" : "McDonald",
               "given" : "Helen I."
            },
            "orcid" : "0000-0003-0576-2015"
         },
         {
            "id" : "",
            "institution" : "London School of Hygiene & Tropical Medicine",
            "name" : {
               "family" : "Nitsch",
               "given" : "Dorothea"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "London School of Hygiene & Tropical Medicine",
            "name" : {
               "family" : "Millett",
               "given" : "Elizabeth R.C."
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "University of Bedfordshire",
            "name" : {
               "family" : "Sinclair",
               "given" : "Alan"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "London School of Hygiene & Tropical Medicine",
            "name" : {
               "family" : "Thomas",
               "given" : "Sara L."
            },
            "orcid" : null
         }
      ],
      "date" : "2015-06-01",
      "date_type" : "published",
      "id_number" : "10.1093/ndt/gfu401",
      "issn" : "0931-0509",
      "language" : "english",
      "official_url" : "https://researchportal.bath.ac.uk/en/publications/are-pre-existing-markers-of-chronic-kidney-disease-associated-wit",
      "publisher" : "Oxford University Press",
      "title" : "Are pre-existing markers of chronic kidney disease associated with short-term mortality following acute community-acquired pneumonia and sepsis? A cohort study among older people with diabetes using electronic health records",
      "type" : "article"
   },
   {
      "abstract" : "Objective: A systematic review of the association of predialysis chronic kidney disease (CKD) with the incidence of acute, community-acquired infections. Design: We searched the MEDLINE, EMBASE and Cochrane databases (inception to 16 January 2014) for studies analysing the association of predialysis kidney disease with the incidence of acute, communityacquired urinary tract infection (UTI), lower respiratory tract or central nervous system infections or sepsis. Studies were required to include at least 30 participants with and without kidney disease. Setting and participants: Community-based populations of adults in high-income countries. Outcome measures: Acute, community-acquired UTI, lower respiratory tract or central nervous system infections or sepsis. Results: We identified 14 eligible studies. Estimates from two studies lacked 95% CIs and SEs. The remaining 12 studies yielded 17 independent effect estimates. Only three studies included infections managed in the community. Quality assessment revealed that probable misclassification of kidney disease status and poor adjustment for confounding were common. There was evidence from a few large high-quality studies of a graded association between predialysis CKD stage and hospitalisation for infection. One study found an interaction with age, with a declining effect of CKD on infection risk as age increased. There was evidence of between-studies heterogeneity (I2=96.5%, p<0.001) which persisted in subgroup analysis, and thus meta-analysis was not performed. Conclusions: Predialysis kidney disease appears to be associated with increased risk of severe infection. Whether predialysis kidney disease increases the susceptibility to infections and whether age modifies this association remains unclear.",
      "creators" : [
         {
            "id" : "him24@bath.ac.uk",
            "institution" : "London School of Hygiene & Tropical Medicine",
            "name" : {
               "family" : "McDonald",
               "given" : "Helen I."
            },
            "orcid" : "0000-0003-0576-2015"
         },
         {
            "id" : "",
            "institution" : "London School of Hygiene & Tropical Medicine",
            "name" : {
               "family" : "Thomas",
               "given" : "Sara L."
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "London School of Hygiene & Tropical Medicine",
            "name" : {
               "family" : "Nitsch",
               "given" : "Dorothea"
            },
            "orcid" : null
         }
      ],
      "date" : "2014-04-17",
      "date_type" : "published",
      "id_number" : "10.1136/bmjopen-2013-004100",
      "issn" : "2044-6055",
      "language" : "english",
      "official_url" : "https://researchportal.bath.ac.uk/en/publications/chronic-kidney-disease-as-a-risk-factor-for-acute-community-acqui",
      "publisher" : "BMJ Publishing Group",
      "title" : "Chronic kidney disease as a risk factor for acute community-acquired infections in high-income countries: A systematic review",
      "type" : "article"
   },
   {
      "abstract" : "Background: While acute kidney injury (AKI) alone is associated with increased mortality, the incidence of hospital admission with AKI among stable and exacerbating COPD patients and the effect of concurrent AKI at COPD exacerbation on mortality is not known. Methods: A total of 189,561 individuals with COPD were identified from the Clinical Practice Research Datalink. Using Poisson and logistic regressions, we explored which factors predicted admission for AKI (identified in Hospital Episode Statistics) in this COPD cohort and concomitant AKI at a hospitalization for COPD exacerbation. Using survival analysis, we investigated the effect of concurrent AKI at exacerbation on mortality (n=36,107) and identified confounding factors. Results: The incidence of AKI in the total COPD cohort was 128/100,000 person-years. The prevalence of concomitant AKI at exacerbation was 1.9%, and the mortality rate in patients with AKI at exacerbation was 521/1,000 person-years. Male sex, older age, and lower glomerular filtration rate predicted higher risk of AKI or death. There was a 1.80 fold (95% confidence interval: 1.61, 2.03) increase in adjusted mortality within the first 6 months post COPD exacerbation in patients suffering from AKI and COPD exacerbation compared to those who were AKI free. Conclusion: In comparison to previous studies on general populations and hospitalizations, the incidence and prevalence of AKI is relatively high in COPD patients. Coexisting AKI at exacerbation is prognostic of poor outcome.",
      "creators" : [
         {
            "id" : "",
            "institution" : "London School of Hygiene & Tropical Medicine",
            "name" : {
               "family" : "Barakat",
               "given" : "M. F."
            },
            "orcid" : null
         },
         {
            "id" : "him24@bath.ac.uk",
            "institution" : "London School of Hygiene & Tropical Medicine",
            "name" : {
               "family" : "McDonald",
               "given" : "H. I."
            },
            "orcid" : "0000-0003-0576-2015"
         },
         {
            "id" : "",
            "institution" : "London School of Hygiene & Tropical Medicine",
            "name" : {
               "family" : "Collier",
               "given" : "T. J."
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "London School of Hygiene & Tropical Medicine",
            "name" : {
               "family" : "Smeeth",
               "given" : "L."
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "London School of Hygiene & Tropical Medicine",
            "name" : {
               "family" : "Nitsch",
               "given" : "D."
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "London School of Hygiene & Tropical Medicine",
            "name" : {
               "family" : "Quint",
               "given" : "J. K."
            },
            "orcid" : null
         }
      ],
      "date" : "2015-09-28",
      "date_type" : "published",
      "id_number" : "10.2147/COPD.S88759",
      "issn" : "1176-9106",
      "language" : "english",
      "official_url" : "https://researchportal.bath.ac.uk/en/publications/acute-kidney-injury-in-stable-copd-and-at-exacerbation",
      "publisher" : "Dove  Medical Press",
      "title" : "Acute kidney injury in stable COPD and at exacerbation",
      "type" : "article"
   },
   {
      "abstract" : "Purpose: People with chronic kidney disease (CKD) have an increased prevalence of depression, anxiety, and neuropathic pain. We examined prevalence, incidence, indication for, and choice of antidepressants among patients with and without CKD. Methods: Using the UK Clinical Practice Research Datalink, we identified patients with CKD (two measurements of estimated glomerular filtration rate < 60 mL/min/1.73m2 for ≥3 months) between April 2004 and March 2014. We compared those with CKD to a general population cohort without CKD (matched on age, sex, general practice, and calendar time [index date]). We identified any antidepressant prescribing in the six months prior to index date (prevalence), the first prescription after index date among non-prevalent users (incidence), and recorded diagnoses (indication). We compared antidepressant choice between patients with and without CKD among patients with a diagnosis of depression. Results: There were 242 349 matched patients (median age 76 [interquartile range 70–82], male 39.3%) with and without CKD. Prevalence of antidepressant prescribing was 16.3 and 11.9%, and incidence was 57.2 and 42.4/1000 person-years, in patients with and without CKD, respectively. After adjusting for confounders, CKD remained associated with higher prevalence and incidence of antidepressant prescription. Regardless of CKD status, selective serotonin reuptake inhibitors were predominantly prescribed for depression or anxiety, while tricyclic antidepressants were prescribed for neuropathic pain or other reasons. Antidepressant choice was similar in depressed patients with and without CKD. Conclusions: The rate of antidepressant prescribing was nearly one and a half times higher among people with CKD than in the general population.",
      "creators" : [
         {
            "id" : "",
            "institution" : "London School of Hygiene & Tropical Medicine",
            "name" : {
               "family" : "Iwagami",
               "given" : "Masao"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "London School of Hygiene & Tropical Medicine",
            "name" : {
               "family" : "Tomlinson",
               "given" : "Laurie A."
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "London School of Hygiene & Tropical Medicine",
            "name" : {
               "family" : "Mansfield",
               "given" : "Kathryn E."
            },
            "orcid" : null
         },
         {
            "id" : "him24@bath.ac.uk",
            "institution" : "London School of Hygiene & Tropical Medicine",
            "name" : {
               "family" : "McDonald",
               "given" : "Helen I."
            },
            "orcid" : "0000-0003-0576-2015"
         },
         {
            "id" : "",
            "institution" : "London School of Hygiene & Tropical Medicine",
            "name" : {
               "family" : "Smeeth",
               "given" : "Liam"
            },
            "orcid" : null
         },
         {
            "id" : "",
            "institution" : "London School of Hygiene & Tropical Medicine",
            "name" : {
               "family" : "Nitsch",
               "given" : "Dorothea"
            },
            "orcid" : null
         }
      ],
      "date" : "2017-04-11",
      "date_type" : "published",
      "id_number" : "10.1002/pds.4212",
      "issn" : "1053-8569",
      "language" : "english",
      "official_url" : "https://researchportal.bath.ac.uk/en/publications/prevalence-incidence-indication-and-choice-of-antidepressants-in-",
      "publisher" : "John Wiley and Sons Inc.",
      "title" : "Prevalence, incidence, indication, and choice of antidepressants in patients with and without chronic kidney disease: a matched cohort study in UK Clinical Practice Research Datalink",
      "type" : "article"
   }
]